Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles
2018
Mitrović Marko B. | Tatalović Nikola R. | Nikolić-Kokić Aleksandra L. | Ciraj-Bjelac Olivera F. | Krstić Nikola E. | Oreščanin-Dušić Zorana S. | Krstić Dragana Ž. | Jovanović Zoran M. | Blagojević Duško P. | Lazarević-Macanović Mirjana V.
In recent years, computed tomography (CT) has become very common in veterinary medicine. It is well known that testicles are organs with high radiosensitivity and their function can be impaired even after exposure to low radiation doses. In this work, we calculated the absorbed radiation doses after CT was performed with different voltage/current levels and correlated it with the activity of antioxidant enzymes in rabbit testicles. Two hours after CT, the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) were increased in the testicles of animals that received an absorbed dose of 29.2 mGy. The same changes, along with elevated glutathione reductase (GR) activity, were observed after 7 days in animals that received the highest absorbed dose (46.3 mGy). It would appear that absorbed doses above 27.8 mGy provoked the antioxidant reaction but the time scale of the reaction was dose-dependent. Examination of the obtained results revealed that the main denominator of CT influence was a higher current. Our results suggest that CT influences the antioxidant status in rabbit testicles. The changes in antioxidant enzyme activities were dose- and time-dependent and influenced by the applied current. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 173014: Molecular mechanisms of redox signaling in homeostasis: adaptation and pathology and Grant 175061: Antioxidant protection and potentials for differentiation and regeneration of mesenchymal stem cells from various tissues during the aging process]
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