AMELIORATING ACTION OF CNIDOSCOLUS ACONITIFOLIUS ON TESTOSTERONE PROPIONATE-INDUCED BENIGN PROSTATE HYPERPLASIA RATS
2024
V. O. Nwobodo | U. A. Ibiam | T. O. Obiekezie | C. M. Chigbo | B. N. Osita | C. M. Nwarienne
Unhealthy lifestyle, high cost of living, non-balance feeding habit and poor exercise are among the major contributory factors to high incidence of benign prostate hyperplasia especially among men of 40 years and above. Improvement of biochemical parameters in testosterone propionate-induced benign prostate hyperplasia (BPH) rats by Cnidoscolus aconitifolius was studied. The 28days study was done using 30 male albino rats grouped into six with 5 rats each. The extraction and characterization of the leaves were done using standard methods. Enzyme assays and other biochemical parameters were determined using spectrophotometric techniques. The results obtained revealed that the administration of Cnidoscolus aconitifolius significantly reduced the Prostate Specific Antigen (PSA), Dihydrotestosterone (DHT), Alkaline phosphatase (ALP) and Inflammatory marker levels when compared with the BPH (negative) control group whose values were elevated. The histopathology assays of the treated groups showed little healing in the prostate as compared to the negative control group. The results suggest that Cnidoscolus aconitifolius possesses anti-BPH potentials and may be encouraged for management of BPH.
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