Pitolisant nanofibers: A promising frontier in drug delivery for narcolepsy - Formulation, optimisation, and characterization insights
2024
J. Nandhini | E. Karthikeyan | C. Jegatheshwaran | K. Vignesh | G. Muthuboopathi | S. Rajeshkumar
The study focuses on developing a new way to deliver the narcolepsy medication pitolisant. Electrospinning was used to make polyvinyl alcohol (PVA) and hyperbranched polyglycerol (HPG) polymers into pitolisant nanofibers (PT-NF). A design expert created the best formulation to optimise the process variables like applied voltage, distance, and feed rate. The nanofibers were characterised using scanning electron microscopy, X-ray diffraction, FT-IR, entrapment efficiency, and in-vitro drug release studies. Results showed that the optimal PT-NF formulation had an average diameter of 172 nm with an entrapment efficacy of 95 % and 92 % drug release within 45 min. HPG polymer was included in the optimised formulation, whose average fibre diameter was 118 nm with 98 % entrapment efficacy and 98 ± 2 % drug release within 30 min. These findings strongly suggest that PT nanofibers hold substantial promise as a viable alternative to conventional solid dosage forms for brain-targeted administration, especially when administered via a transdermal patch to a patient during sleep.
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