The influence of silicium compounds on the content of calcium, phosphorus and some lipides in the plasma blood

The aim of the study was to investigate the effects of nanotechnology and sodium metasilicate on the content of total calcium and inorganic phosphorus and individual lipids in the blood of rabbits from 52 to 110 days of life. Studies were conducted on young rabbits of Hyla breed in the private sector. Rabbits for the study were selected at the age of 41 days on the principle of analogues, weighing 1.2–1.4 kg, were divided into six groups (control and five experimental), 6 animals (3 males and 3 females) in each. Animals were kept in with adjustable microclimate and illumination in mesh cages measuring 50×120×30 cm, in accordance with modern animal health standards. The control group rabbits were fed without restriction a balanced granular compound feed, with free access to water. Animals I, II, and III of the study groups were fed a control group diet and fed citrate silicon for 24 hours, with a corresponding rate of 25; 50 and 75 µg Si/kg body weight. Young animals of the IV and V experimental groups were fed wit diet of the control group and water was given sodium metasilicate (Na2SiO3H2O) in the amount of 2.5 and 5.0 mg Si/kg body weight, respectively. The experiment lasted 68 days, including the preparatory period of 10 days, the experimental period – 58 days. In the preparatory period – at 52 days and experimental at 83 and 110 days of life (31 and 58 days of drinking additives) in 4 animals (2 males and 2 females) from the group blood samples were taken for biochemical studies. Studies have found that the concentration of total calcium in the blood plasma of rabbits III and IV study groups was higher by 9.6 and 6.4% (P < 0.05) for 58 days of the study compared with the control, indicating the stimulating effect of the organic compound silicon to activate the processes of assimilation of this macronutrient in the body of young rabbits. Silicone citrate in the large test quantities and sodium metasilicate in the blood plasma of animals of III, IV and V experimental groups respectively increased the level of inorganic phosphorus by 35.7; 28.5 and 35.7% (P < 0.05) than controls at day 58 of the study. In the final study period, the ratio of Calcium to Phosphorus in the animals of the II – V experimental groups was in the range of 2.0–1.73: 1, indicating a more pronounced effect of silicon compounds on the metabolism of Phosphorus during a longer period of supplementation. The content of triacylglycerols in the blood plasma of rabbits II and III of the experimental groups was lower (P < 0.05) at 31 and 58 days of the study compared with the control. The results obtained may indicate the activation of the processes of metabolic accumulation of plastic components of cell membranes and energy needs of body tissues. The use of silica organic compound reduced the cholesterol content by 37% (P < 0.05) in the blood of rabbits of the III experimental group at 31 days of the study. Whereas at the final stage of the experiment in animals II; In the 3rd and 4th research groups, its level was lower by 43.4; 36.9 and 42.2% (P < 0.05) compared to the control, indicating greater use of cholesterol by the organism with silica organic compound.