Development of an analytical method for the simultaneous determination of iminoctadine, diquat, and paraquat in drinking water using LC/MS/MS
2015
Kobayashi, N. (National Institute of Health Sciences, Setagaya-ku, Tokyo (Japan). Division of Environmental Chemistry) | Kubota, R. | Sasaki, S. | Ikarashi, Y.
We have developed a liquid chromatography-tandem mass spectrometry (LC/MS/MS) analytical method for the simultaneous determination of 3 agricultural chemicals (iminoctadine, diquat, and paraquat) considered 'complementary items' in drinking water under the Japanese Waterworks Act. Further, we evaluated the validity of the analytical method based on the results of recovery tests of each chemical from dechlorinated tap water. In the LC/MS/MS measurement of a standard solution of a mixture of agricultural chemicals, the linearity of a calibration curve and the reproducibility of repeat measurements were satisfactory. Moreover, the quantification limits were lower than 1/100 of the desired values of each chemical. Recovery tests using dechlorinated tap water suggested satisfactory recovery rates (74 to 91%) and reproducibility (3 to 7%) for each of the tested chemicals. The results satisfied the criteria of the Japanese guideline regarding water quality analysis established by the Ministry of Health, Labour and Welfare. Therefore, we propose that the simultaneous analytical method we have developed in the present study is applicable to the analysis of the 3 agricultural chemicals in drinking water.
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