Production of monodisperse oil-in-water emulsions using asymmetric micro through-holes compactly arranged on a metallic chip
2016
Kobayashi, I. (National Food Research Institute, National Agriculture and Food Research Organization, Tsukuba, Ibaraki (Japan)) | Zhang, Y. | Li, R. | Uemura, K. | Nakajima, M.
The aim of this study was to produce monodisperse oil-in-water (O/W) emulsions using a metallic microchannel emulsification (MCE) chip containing 171 compactly arranged asymmetric micro through-holes. Each asymmetric micro-though-hole that was fabricated on an aluminum chip consisted of a circular microhole with a 100-micro m diameter (1650-micro m depth on the inlet side) and a microslot on the outlet side with a 100 * 700-micro m cross-section and 350-micro m depth. Uniformly sized silicone oil droplets with an average diameter (dsub(av)) of 291.5 micro m and the coefficient of variation (CV) of 3.9% were smoothly formed by means of the asymmetric micro through-holes at the flow rate of the dispersed phase (Qsub(d)) of 1.0 mL/h without a cross-flowing continuous phase. Metallic MCE chips have advantages over silicon MCE chips in terms of durability vis-a-vis alkaline cleaning and shocks as well as modifications of through-hole dimensions.
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