Lignosulfonic acid-induced inhibition of intestinal glucose absorption
2015
Hasegawa, Y. (Muroran Institute of Technology, Muroran (Japan). College of Environmental Technology) | Kadota, Y. | Hasegawa, C. | Kawaminami, S.
Lignosulfonic acid is a waste lignin produced from the sulfite pulping of softwood. We investigated the effect of lignosulfonic acid on alpha-glucosidase and found that lignosulfonic acid produced a reversible and non-competitive inhibition of the enzyme activity. Moreover, in human colorectal adenocarcinoma cells, lignosulfonic acid inhibited 2-deoxyglucose uptake, while in vivo studies demonstrated a significant reduction in the blood glycemic response to sucrose or glucose ingestion in rats treated with lignosulfonic acid. Feces of rats fed a diet supplemented with 5% lignosulfonic acid had higher sugar content compared to those of rats fed a control diet. These results suggest that lignosulfonic acid suppresses the rise in blood glucose levels through inhibition of alpha-glucosidase activity and intestinal glucose absorption.
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