Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats
2016
Kanai, K. (University of Kitasato, Towada, Aomori (Japan). School of Veterinary Medicine, Department of Small Animal Internal Medicine I) | Nagata, S. | Hatta, T. | Sugiura, Y. | Sato, K. | Yamashita, Y. | Kimura, Y. | Itoh, N.
The present study aimed to investigate the therapeutic efficacy of post-inflammatory treatment with luteolin on endotoxin-induced uveitis (EIU) in rats. Intraperitoneal injection of 10 mg/kg luteolin or 1 mg/kg prednisolone (Pred) at 4 hr post-lipopolysaccharide (LPS) injection (200 micro g) was associated at 24 hr post-LPS injection with decreased clinical severity scores, number of inflammatory cells, protein levels and levels of tumor necrosis factor (TNF)-alpha, nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor (AqH) and degrees of histological ocular tissue injury. The anti-inflammatory potency of luteolin was comparable to that of Pred. Luteolin exhibited robust efficacy in the treatment of EIU in rats, indicating its potential clinical utility in treating uveitis.
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