Outbreak of tuberculosis in cynomolgus monkeys (Macaca fascicularis) imported to Japan
2018
Oe, S. (Ministry of Agriculture, Forestry and Fisheries, Narita (Japan). Animal Quarantine Service, Narita Branch) | Okamura, N. | Akuzawa, Y. | Chikamatsu, K. | Yamada, H. | Murase, Y. | Mitarai, S.
Thirty-two cynomolgus monkeys (Macaca fascicularis) under import quarantine at the Animal Quarantine Service in Japan were examined for tuberculosis by tuberculin skin test. Nine of the 32 showed positive and/or suspicious reactions. Although they had no apparent symptoms suggestive of tuberculosis, pulmonary multifocal nodular lesions were present with acid-fast positive bacilli on some tissue samples, such as the lungs and lymph nodes. Mycobacterium tuberculosis was isolated from some tissue samples. The results of the tuberculin skin test and histopathological findings indicated that Mycobacterium tuberculosis might have infected some monkeys more than a few months prior to the test, and expanded in the same colony. The genotype of the isolated Mycobacterium tuberculosis was determined as EAI2_MANILLA by spoligotyping.
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