Pathology and transmission of avian amyloid A amyloidosis
2020
Murakami, T. (Tokyo University of Agriculture and Technology, Fuchu, Tokyo (Japan). Faculty of Agriculture, Cooperative Department of Veterinary Medicine, Laboratory of Veterinary Toxicology)
Amyloid A (AA) amyloidosis is the most common amyloidosis in animals and is observed in several mammals and bird species. As serum AA, the precursor protein of AA, is an inflammatory protein, AA amyloidosis is secondary to chronic inflammatory diseases. Therefore, in chickens and quails, AA amyloidosis is induced by continual inflammatory stimuli such as vaccinations. In recent years, amyloid deposits have been found in commercially available foie gras and in the skeletal muscle of retired layer hens. As cross-species transmission of AA amyloidosis has been experimentally demonstrate to occurs via amyloid ingestion the possibility of transmission of amyloidosis from livestock to livestock or from livestock to humans is a concern. Understanding the pathogenesis and transmissibility of AA amyloidosis is very important to clarify the means of horizontal transmission between animals and the risk of transmission to humans. Here, the pathology and transmission of AA amyloidosis poultry is outlined with the aim of improve the current understanding of this disease in poultry.
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