Characterization of shiga toxin subtypes in enterohemorrhagic Escherichia coli isolated in Aichi Prefecture from 2009 to 2018
2020
Takahashi, Y. | Yamada, K. | Aoki, M. | Nakane, I. | Yotsumoto, S. | Tsuduki, H. | Matsumoto, M.
About 4,000 cases of enterohemorrhagic Escherichia coli (EHEC) infection are reported annually in Japan. EHEC infection is considered to be a problem, because it may cause hemolytic uremic syndrome (HUS) and encephalopathy, which may lead to death. In recent years, it has been reported that the shiga toxin (stx) subtype possessed by EHEC is related to the severity. In this study, we investigate the serotypes and stx subtypes of EHEC isolates in Aichi Prefecture from 2009 to 2018. A total of 255 EHEC isolates were examined. The most predominant serotypes were O157 (181 isolates, 71.0 %), followed by O26 (40 isolates, 15.7 %). As for stx and the subtypes, 56 isolates (22.0 %) carried only stx1, and the all was stx1a. stx2a and stx2c were only detected among subtypes of stx2. The most frequently detected combination of stx subtypes in O157 was stx1a + stx2a (101 isolates, 57.1 %), followed by stx1a + stx2c (28 isolates, 15.8 %). In addition, the total rate of stx2a, stx2a + stx2c and stx1a + stx2a, which are often separated from severe patients, was high (71.2 %). In order to infer the severity and prognosis of the patients, it is important to continue to investigate the distribution of the serotypes and stx subtypes of EHEC isolates.
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