Relevance of gut microbiome research in food safety assessment
2024
Garrido-Romero, Manuel | Pazos, Florencio | Sánchez-Martínez, Elisa | Benito, Carlos | Gómez-Ruiz, José Ángel | Borrego Yaniz, Gonzalo | Bowes, Cameron | Broll, Hermann | Caminero, Alberto | Caro, Eleonora | Chagoyen, Mónica | Chemaly, Marianne | Fernández-Dumont, Antonio | Gisavi, Haris | Gkrintzali, Georgia | Khare, Sangeeta | Margolles, Abelardo | Márquez, Ana | Martín, Javier | Merten, Caroline | Montilla, Antonia | Muñoz Labrador, Ana | Novoa, Jorge | Paraskevopoulos, Konstantinos | Payen, Cyrielle | Withers, Helen | Ruas-Madiedo, Patricia | Ruiz, Lorena | Sanz, Yolanda | Jiménez-Saiz, Rodrigo | Moreno, F. Javier | European Food Safety Authority | European Commission | Instituto de Salud Carlos III
The gut microbiome is indispensable for the host physiological functioning. Yet, the impact of non-nutritious dietary compounds on the human gut microbiota and the role of the gut microbes in their metabolism and potential adverse biological effects have been overlooked. Identifying potential hazards and benefits would contribute to protecting and harnessing the gut microbiome's role in supporting human health. We discuss the evidence on the potential detrimental impact of certain food additives and microplastics on the gut microbiome and human health, with a focus on underlying mechanisms and causality. We provide recommendations for the incorporation of gut microbiome science in food risk assessment and identify the knowledge and tools needed to fill these gaps. The incorporation of gut microbiome endpoints to safety assessments, together with well-established toxicity and mutagenicity studies, might better inform the risk assessment of certain contaminants in food, and/or food additives.
اظهر المزيد [+] اقل [-]This research was funded by the European Food Safety Authority[grant number GP/EFSA/ENCO/2020/02-1]. RJS is supported byFSE/FEDER through the Instituto de Salud Carlos III [ISCIII;CP20/00043]. The project of the European Union’s Horizon 2020Program CIRCLES (Grant Agreement nº818290) to YS isacknowledged.
اظهر المزيد [+] اقل [-]Peer reviewed
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Instituto de Agroquímica y Tecnología de Alimentos