PRODUCTION AND EVALUATION OF NANOLIPOSOMES LOADED WITH CAPPARIS SPINOSA EXTRACT
2022
Rezvan Shaddel | Younes Zahedi | Masoumeh Salamatian
In this study, after extracting capparis spinosa extract and determining the amount of its phenolic compounds, nanoliposomes containing capparis spinosa extract were prepared in different ratios of lecithin and cholesterol. Then, the effect of cholesterol-lecithin concentrations on particle size, particle size distribution, encapsulation efficiency (EE), physical stability of nano- liposomes and stability of phenolic compounds loaded in nano-liposomes during the storage time were evaluated. The amount of phenolic compounds were obtained 6.328 mg of GAE/g dry sample. The average particle size as Z-Average was in the range of 95.05-164.25 nm. By increasing the cholesterol concentration, particle size increased. The particle size distribution was in the acceptable range of 0.3-0.5 (PI≤0.5). Addition of cholesterol increased zeta potential from -60.40 to -68.55. Higher zeta potential values, indicate a higher and longer- term stability of the particles. Also, cholesterol led to increase encapsulation efficiency (EE) and even the stability of phenolic compounds loaded in nano- liposomes during storage time. The results showed that the problem of instability of phenolic compounds, which leads to their limited commercial application, can be solved by encapsulation.
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