A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases
2024
Liang, Zaolan | Lin, Xia | Sun, Lihong | Edwards, Kimberly, M | Song, Wenjun | Sun, Hailiang | Xie, Yanmin | Lin, Fangmei | Ling, Shiman | Liang, Tingting | Xiao, Biying | Wang, Jiaqi | Li, Min | Leung, Chin-Yu | Zhu, Huachen | Bhandari, Nisha | Varadarajan, Raghavan | Levine, Min, Z | Peiris, Malik | Webster, Robert | Dhanasekaran, Vijaykrishna | Leung, Nancy, H L | Cowling, Benjamin, J | Webby, Richard, J | Ducatez, Mariette | Zanin, Mark | Wong, Sook-San | Centre de recherche Université de Hong-Kong - Pasteur / University of Hong Kong - Pasteur Research Pole (HKU-PRP) ; Pasteur Network (Réseau International des Instituts Pasteur) | LKS Faculty of Medicine (HKU Med) ; The University of Hong Kong (HKU) | Southern Medical University [Guangzhou] | Guangdong General Hospital [Guangzhou] (MICURAE) | Guangzhou National Laboratory, No. 9 XingDaoHuanBei Road, Guangzhou International Bio Island, Guangzhou, 510005, Guangdong Province, China | South China Agricultural University (SCAU) | The Chinese University of Hong Kong [Hong Kong] (CUHK) | Indian Institute of Science [Bangalore] (IISc Bangalore) | Centers for Disease Control and Prevention [Atlanta] (CDC) ; Centers for Disease Control and Prevention | St Jude Children's Research Hospital [Memphis, USA] | Interactions hôtes-agents pathogènes [Toulouse] (IHAP) ; Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
International audience
اظهر المزيد [+] اقل [-]إنجليزي. Abstract Human cases of avian influenza virus (AIV) infections are associated with an age-specific disease burden. As the influenza virus N2 neuraminidase (NA) gene was introduced from avian sources during the 1957 pandemic, we investigate the reactivity of N2 antibodies against A(H9N2) AIVs. Serosurvey of healthy individuals reveal the highest rates of AIV N2 antibodies in individuals aged ≥65 years. Exposure to the 1968 pandemic N2, but not recent N2, protected against A(H9N2) AIV challenge in female mice. In some older adults, infection with contemporary A(H3N2) virus could recall cross-reactive AIV NA antibodies, showing discernable human- or avian-NA type reactivity. Individuals born before 1957 have higher anti-AIV N2 titers compared to those born between 1957 and 1968. The anti-AIV N2 antibodies titers correlate with antibody titers to the 1957 N2, suggesting that exposure to the A(H2N2) virus contribute to this reactivity. These findings underscore the critical role of neuraminidase immunity in zoonotic and pandemic influenza risk assessment.
اظهر المزيد [+] اقل [-]المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique
