Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity
2020
Scherf, Katharina | Catassi, Carlo | Chirdo, Fernando | Ciclitira, Paul | Feighery, Conleth | Gianfrani, Carmen | Koning, Frits | Lundin, Knut | Schuppan, Detlef | Smulders, Marinus | Tranquet, Olivier | Troncone, Riccardo | Koehler, Peter | Karlsruhe Institute of Technology = Karlsruher Institut für Technologie (KIT) | Polytechnic University of Marche / Università Politecnica delle Marche (UNIVPM) | Univ Nacl La Plata, Inst Bot Spegazzini, RA-1900 La Plata, Buenos Aires, Argentina ; Univ Nacl La Plata, Inst Bot Spegazzini, RA-1900 La Plata, Buenos Aires, Argentina | University of East Anglia [Norwich] (UEA) | Dublin City University [Dublin] (DCU) | Italian National Research Council (CNR) ; Italian National Research Council (CNR) | Leiden University Medical Center (LUMC) ; Universiteit Leiden = Leiden University | Oslo University Hospital [Oslo] | Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU) | Wageningen Univ, Lab Plant Breeding ; Wageningen University and Research [Wageningen] (WUR) | Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA) ; Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | "Federico II" University of Naples Medical School | Biotask AG, | Arbeitsgemeinschaft Getreideforschung e.V. (Association of Cereal Research), Detmold, Germany.
International audience
اظهر المزيد [+] اقل [-]إنجليزي. Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique