Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution
2008
Griffin, Darren K. | Robertson, Lindsay B. | Tempest, Helen G. | Vignal, Alain | Fillon, Valerie | Crooijmans, Richard Pma | Groenen, Martien Am | Deryusheva, Svetlana | Gaginskaya, Elena | Carré, Wilfrid | Waddington, David | Talbot, Richard | Völker, Martin | Masabanda, Julio S | Burt, Dave W | University of Kent | London Bioscience Innovation Centre ; Partenaires INRAE | University of Calgary | Laboratoire de Génétique Cellulaire (LGC) ; Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT) | Animal Breeding and Genomics Centre ; Wageningen University and Research [Wageningen] (WUR) | Saint Petersburg State University (SPBU) | The University of Edinburgh | The Roslin Institute ; Biotechnology and Biological Sciences Research Council (BBSRC)
International audience
اظهر المزيد [+] اقل [-]إنجليزي. Background: Comparative genomics is a powerful means of establishing inter-specific relationships between gene function/location and allows insight into genomic rearrangements, conservation and evolutionary phylogeny. The availability of the complete sequence of the chicken genome has initiated the development of detailed genomic information in other birds including turkey, an agriculturally important species where mapping has hitherto focused on linkage with limited physical information. No molecular study has yet examined conservation of avian microchromosomes, nor differences in copy number variants (CNVs) between birds. Results: We present a detailed comparative cytogenetic map between chicken and turkey based on reciprocal chromosome painting and mapping of 338 chicken BACs to turkey metaphases. Two inter-chromosomal changes (both involving centromeres) and three pericentric inversions have been identified between chicken and turkey; and array CGH identified 16 inter-specific CNVs. Conclusion: This is the first study to combine the modalities of zoo-FISH and array CGH between different avian species. The first insight into the conservation of microchromosomes, the first comparative cytogenetic map of any bird and the first appraisal of CNVs between birds is provided. Results suggest that avian genomes have remained relatively stable during evolution compared to mammalian equivalents.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique