A Critical Review of the CRISPR-Cas Technology in the Detection of SARS-CoV-2 Variants
2025
Jie Zhang | Juezhuo Li | Jiawei Zhou | Jiaye Zhong | Yue Xu | Xiaolei Mao | Minghui Xu | Shuyin Luo | Yi Yang | Ruiyao Hu | Dong-Ang Liu | Shiyu Chen | Yuting Qiu | Keyi Chen | Jinghua Yuan | Xinling Zhang | Xiaoping Li
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still going on, and as the epidemic situation continues, the genome of SARS-CoV-2 is also mutating and evolving, resulting in more and more SARS-CoV-2 mutant strains, which have brought serious pressure on the prevention and control of COVID-19. Given that the COVID-19 is still spreading, it is extremely important to rapidly identify SARS-CoV-2 variants by nucleic acid assays. Thus, developing highly sensitive and specific assays that are suitable for field testing, high-throughput, and automation, as well as other diagnostic applications for SARS-CoV-2 variants, is urgently needed. This paper reviews the research progress of novel CRISPR-based diagnostic methods for SARS-CoV-2 variants.
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