Mice immunization with live<em> lactococci</em> displaying a surface anchored HPV-16 E7 oncoprotein.
2003
Cortes-Perez, Naima G | Bermudez Humaran, Luis | Le Loir, Yves | Rodríguez-Padilla, Cristina | Gruss, Alexandra, A. | Saucedo-Cardenas, Odila | Langella, Philippe, P. | Montes-De-Oca-Luna, Roberto | Universidad Autonoma de Nuevo Leon [Mexique] (UANL) | Institut National de la Recherche Agronomique (INRA) | Bactéries Lactiques et Pathogènes Opportunistes (UBLO) ; Institut National de la Recherche Agronomique (INRA) | Unité mixte de recherche science et technologie du lait et de l'oeuf ; Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST | Centro de Investigaciones Biomédicas ; Universidad Andrés Bello [Santiago] (UNAB)-Fondecyt 3130762 | Universitad Autonoma de Nuevo Leon ; Partenaires INRAE
International audience
اظهر المزيد [+] اقل [-]إنجليزي. E7 oncoprotein of human papillomavirus-16 (HPV-16) is constitutively produced in cervical cancer (CxCa) and is a good candidate for the design of therapeutic vaccines. In this work, the nisin-controlled expression system was used to display the E7 protein at the cell surface of the food-grade Gram-positive bacterium Lactococcus lactis. An efficient cell wall anchoring of E7 was obtained. Intranasal administration of these recombinant lactococci in mice induced an HPV-16 E7-specific immune response. This is the first report of E7 cell wall anchoring in L. lactis and represents one more step towards the use of live food-grade bacteria to fight against CxCa.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique