EFFECT OF CHITOSAN SHEET ON INFLAMMATION IN RABBITS

Jasim M. Al-Diab; and Manal; A Ala Al-Deen H. J awad

EFFECT OF CHITOSAN SHEET ON INFLAMMATION IN RABBITS

2006

Jasim M. Al-Diab | and Manal | A Ala Al-Deen H. J awad

This study was conducted to investigate the effect of chitosan sheets onA inflammation. Accordingly chitosan sheet was isolated and prepared from theexoskeleton of the native shrimps in Basrah Province. The inﬂammation was induced andevaluated by polyvinyl sponge to determine the events which occur during theinﬂammatory process during different intervals in the presence or absence of chitosan‘ sheets .For this purpose 24 male rabbits were used and two linear skin incisions (2 cm)were made on the dorsal aspect in both sides of each rabbit. The inflammatory process atl,3,7&l5 day post wounding was evaluated macroscopically in terms of hyperemia,suppuration, dryness, and adhesion of margins and microscopically in terms of infiltrationof inﬂammatory cells specially neutrophils and macrophages, fibrovascular granulationtissue. _. The ‘results of macroscopic evaluation revealed that '-It first post wounding day thetest wound was significantly (p<0.05) more hyperemic than control wounds followed bya significant decrease in the severity of hyperemia in test wounds at ls‘, 3rd, 7"‘, and 15"‘post wounding days (p<0.05). The test wounds was more dry with less suppuration to_ words the end of the experiment than control wounds (p<0.05). The adhesive contactbetween the margin of the wounds was significantly higher in test wounds than in controlwounds through out the period of experiment (p<0.05).

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