ANTI—NOCICEI’TIVE EFFECT OF NI GELLA SA T I VA OIL, APPLE VINEGAR, HONEY AND THEIR COMBINATIONS INLABORATORY MOUSE
2006
Ala Al-Deen H. J awad | and Abdullah M..Jawad | Nowfel H. J assim
An attempt wasmade to study the analgesic effect of oil extract of Nigella sativa . seed, apple vinegar, honey and their combination. These materials were administered orally to male mice and were tested using a model of animal of pain (hot plate test). The result showed that N. sativa oil had a good analgesic effect, increasing hot plate latencies by 57.7%. Similar analgesic effect was produced by apple vinegar. Honey was much less effective; it produced only 52% increase in hot plate time. The effect of apple vinegar and honey was dose dependent. Combination of N. sativa with vinegar or honey did not result in enhancement of effect of N. saliva oil when measured, one hour after administration. However, potentiation effect was found between N. sativa oil and apple vinegar when the analgesic effect was measured at 4 and 6 hours after oral administration.
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