EFFECTS OF THE CYCLOSPORINE ON SOME  HEMATOLOGICAL INDICES IN BONE MARROW  TRANSPLANTED-RABBIT

Alaa A.Sawad; Adel Ch. Awid Abdulbary A. Alfaris

EFFECTS OF THE CYCLOSPORINE ON SOME HEMATOLOGICAL INDICES IN BONE MARROW TRANSPLANTED-RABBIT

2014

Alaa A.Sawad | Adel Ch. Awid Abdulbary A. Alfaris

This study was conducted to evaluate the effects of cyclosporine on some hematological indices in male rabbits after bone marrow transplantation operation. Thirty male rabbits were used in the present study which divided into three groups equally (ten rabbit each group).Rabbit of first group were give0.5 ml of normal slain from Day zero till Day 10 of experiment then applied to intra bone marrow-Bone marrow transplantation (IBM-BMT) at Day 11 then after, these rabbit give normal slain from Day 12 till Day 20 and considered as shame group. Rabbits of second and third groups were applied to same protocol that used in first group except that the rabbit were give 12.5 (T1) and (T2) 25 mg/kg/BW of cyclosporine respectively instead of normal slain. blood was collected At Day10 and Day 21 from all rabbit of the experiment via heart puncture and Red blood cell (RBCs)count , white blood cell (WBCs) count, Deferential leukocyte count, Packed cell volume(PCV) and hemoglobin concentration(Hb) were measured. Results of the present study showed significant decrease (p

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