HIGH EXPRESSION OF P53 PROTEIN IN TOXOPLASMOSIS AMONG WOMEN WITH SPONTANEOUS MISCARRIAGE IN BASRAH

Emarah; Maysoon sharief; Ghazi Y . AL; Muntaha A. H. Nasir

HIGH EXPRESSION OF P53 PROTEIN IN TOXOPLASMOSIS AMONG WOMEN WITH SPONTANEOUS MISCARRIAGE IN BASRAH

2015

Emarah | Maysoon sharief | Ghazi Y . AL | Muntaha A. H. Nasir

Recurrent abortion is a worldwide problem, with undefined causes. Apoptosis could play a major role in the process. The Objective of the work to detect the expression of p53 protein at the materno-fetal interface in patients with recurrent pregnancy loss (RPL). Immunohistochemistry analysis of P53 protein using paraffin embedded sections of curate samples obtained from 40 women divided into three groups : 16 women with recurrent abortion as postive with toxoplasmosis,10 women with recurrent abortion negative of toxoplasmosis and14 women with no histry of abortion as control group . The mean value of the expression of P53 protein was (40.87± 7.54),which is significantly higher than that of the second group(28.2± 4.89),and the third group (13.07± 4.49). The high expression of p53 protein in women with RPL may have a role in accelerating placental apoptosis leading to failure of pregnancy.

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