ANTI-INFLAMMATORY ACTIVITY OF LOSARTAN IN  EXPERIMENTALLY-INDUCED RESPIRATORY DISEASE IN  RAT MODEL

Wamedh Hashim Abbas; Manal A. Algaem

ANTI-INFLAMMATORY ACTIVITY OF LOSARTAN IN EXPERIMENTALLY-INDUCED RESPIRATORY DISEASE IN RAT MODEL

2016

Wamedh Hashim Abbas | Manal A. Algaem

This study was carried out to evaluate the anti-inflammatory effect of losartan in 18 female rats which were divided into 3 groups. Respiratory disease were experimentally induced by the intraperitoneal injection and spray inhalation of ovalbumin (OVA) in first and second group while third group left as negative control group. First group were treated with losartan orally at dose rate of 5 mg/kg body weight, on the other hand second group considered as positive control group. ELISA test were used to estimate the concentration of TNF-α, IL-4 in BALF and total IgE in serum samples. Total WBC, neutrophil, eosinophil and lymphocyte were counted in bronchoaleveolar lavage (BAL). First and second rat groups show signs of pulmonary disease. Losartan treated group showed significant (p

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