THE EFFECTS OF 4̄,4 ̄̄ -(4,5,6,7-TETRAHYDRO- [1,2,3-] SELENADIAZOLO [4,5E] PYRIDINE-4,6-DIYL) BIS(BENZENE-1,3-DIOL) ON FERTILITY, REPRODUCTIVE HORMONES AND OVARIAN HISTOLOGICAL CHANGES IN FEMALE RATS TREATED WITH DIPYRONE.

The current study aimed to evaluate the effects of [ 4’,4” -(4,5,6,7-tetrahydro- [1,2,3-] selenadiazolo[4,5e] pyridine-4,6-diyl) bis(benzene-1,3-diol)] (T) on female fertility and reproductive hormones, in addition histopathological examination of ovaries in comparison with the effects of Metamizole or Dipyrone (Di). Four groups of mature female rats each group consist of ten healthy female rats. Three groups received T and /or Di dissolved in drinking water 2mL (DW), the forth group received 2 mL of (DW) for 20 days before mating and ten days after mating. The results indicated that there was a significant increase in the number of births of (T) group (13.70±3.34) compared to DW group (9.7±1.06). Also, significant decline in T&Di group to (6.91±0.32), with no pregnancies reported in Di treated group. The pregnancy percentage was in T&Di group basically decline to 40% compare with T and DW groups 100%. Follicle stimulating Hormone (FSH) level showed a significant elevation (p<0.05) in T group (5.19mIU/mL ±0.72), and T&Di (5.12 mIU/mL ±0.78) compared with DW (1.61mIU/mL±0.52), and Di (1.46 mIU/mL ±0.60) groups. LH concentration of T (1.88 mIU/mL ±0.48), and T&Di (1.67 mIU/mL ±0.41) groups LH values than in DW (1.75 mIU/mL ±0.67). Only in Di group (0.88 mIU/mL ±0.48) LH value reduced significantly (p<0.05) than in other test groups. T group (17.22 mIU/mL ±4.50) progesterone level; also T&Di group progesterone level (10.11 mIU/mL ±2.05) statistically important increase, while Di group there is essentially decreased (p<0.05) to (2.69 mIU/mL±0.89) compare to DW (6.31 mIU/mL ±1.41). Histopathological results showed that ovarian section of Di group disclosed large cystic corpus luteum CC.L, absence of Graafian Follicles and follicles at different stages of development.  T group section showed normal Graafian follicles and different follicles in developmental stages, as well as there were several persistence corpus luteum. Ovary of T&Di female rats relieves improvement of some Graafian follicles, Cystic corpus luteum (CC.L). Furthermore, there was some of clear C.L. It can be concluded that T compound had a Good effect on the level of reproductive hormones and increase fertility in female rats. While Di long term treatment had bad effects on female fertility, by affecting reproductive hormones levels and pathological change of ovaries.