Anti-obesity and anti-diabetic effects of fermented Momordicae charantiae fructus with Lactobacillus plantarum CBT-LP3
2024
Kwak, S.H. | An, B.C. | Ahn, J.Y. | Lee, J.S. | Chung, M.J. | Ryu, Y.K.
As the prevalence of diabetes in South Korea continues to rise, there is a rapid increase in the prescription rate of oral hypoglycemic agents. Given that these medications need to be taken for a lifetime, there is a necessity to develop treatments that ensure long term safety and devoid of any side effects. Although much research has been conducted on the development of alternative drugs using plant-derived extracts, the active ingredients obtained through general extraction methods have limited effectiveness. Therefore, it is necessary to develop materials that maximize efficacy. Traditionally, Momordicae charantiae (MC) has been known for its effective anti-diabetic properties, so we utilized our own lactic acid bacteria, L. plantarum CBT-LP3, to enhance the anti-diabetic efficacy of MC. In the present study, we assessed the anti-diabetic and anti-obesity activities of bio-fermented M. charantiae fructus (BMC) using in vitro exams. The results demonstrated that the BMC increased glucose uptake through Glut4 induction in 3T3-L1 adipocytes. The BMC also effectively decreased lipid accumulation compared to untreated adipocytes. Furthermore, we found that the BMC substantially induced fat browning compared to untreated adipocytes. BMC, as another property, significantly increased reviving and recovering partially destroyed β cells by streptozotocin (STZ) treatment. This result suggests that BMC can protect and help to recover β cells against damage. In addition, BMC improved β cell dysfunction in high glucose conditions and protected against oxidative stress-induced diabetes. In conclusion, this study demonstrated that the fermentation of M. charantiae fructus using CBT-LP3 enhanced its anti-diabetic and anti-obesity effects.
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