Study of biological safety of camel milk after treatment with different antibiotics
2025
Bilal, Zauresh | Amutova, Farida | Kabdullina, Zaira | Utemuratova, Dariga | Kondybayev, Askar | Akhmetsadykova, Shynar | Musayev, Zhaidar | Akhmetsadykov, Nurlan | Faye, Bernard | Konuspayeva, Gaukhar | Al-Farabi Kazakh National University [Almaty] (KazNU) | Antigen LLP | INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes (INSPIIRE) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL) | Démarche intégrée pour l'obtention d'aliments de qualité (UMR QualiSud) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Avignon Université (AU)-Université de La Réunion (UR)-Institut Agro Montpellier ; Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM) | Antigen Co. Ltd., Almaty Region, 4 Azerbayev Str., Almaty 040905, Kazakhstan | Systèmes d'élevage méditerranéens et tropicaux (UMR SELMET) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier ; Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro) | Département Environnements et Sociétés (Cirad-ES) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) | This study was conducted in the frame of research project AP14871571 financed by the Ministry of Science and High Education of Republic of Kazakhstan and also in the frame of research project BR22886598financed by the Ministry of Agriculture of Republic of Kazakhstan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
International audience
اظهر المزيد [+] اقل [-]إنجليزي. The use of antibiotics in camels is generally based on the doses applied to cattle, despite the known differences in plasma pharmacokinetics between camel and cattle. The demand for camel milk increased due to the belief that traditional camel farming practices produce safe milk with health benefits. For assessing the importance of antibiotic residues in camel milk and to propose a convenient withdrawal period, a trial was conducted on 10 lactating camels (7–12 years old; 450 kg life weight (LW), 7–8 liter of milk production per day) at mid-lactation receiving an injection of 40 mL of Pen-strep® (benzylpenicillin-procaine 200,000 IU/1 ml and dihydrostreptomycin sulfate 200 mg/1 ml) and Nitox® (oxytetracycline dihydrate 200 mg/1 ml). The antibiotic residues were measured in the milk 30 min after injection then on day 1, 2, 3, 7, 9, 14, 19, 24 and 56 by using HPLC-MS/MS. Results showed that penicillin’s mean residual concentration (0.3 ± 0.013 mg/kg) remained 7.5 times above the maximum residue limit (MRL) even on 56th day. In contrast, streptomycin fell below the MRL within 30 minutes and averaged 1 µg/kg by day 56. Oxytetracycline levels exceeded the MRL (0.1 mg/kg) until day 14 but dropped to a safe level of 0.018 ± 0.01 mg/kg by day 24. In conclusion, the decline in streptomycin concentration post-injection appeared rapid and efficient, the elimination of penicillin and tetracycline was slow. These preliminary results lead to considering the necessity to adapt the waiting time to the dairy camel.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique