Molecular modelling of FtsZ proteins based on their homology in Escherichia coli and Mycobacterium tuberculosis as the key stage of rational design of new antituberculous compounds | Molekularno modeliranje proteinov FtsZ na osnovi njihove homologije v Escherichia coli in Mycobacterium tuberculosis kot ključna stopnja racionalnega oblikovanja novih protituberkuloznih komponent
2011
Demchuk, Oleh | Karpov, Pavel | Raspor, Peter | Blume, Yaroslav | Demchuk, Oleh | Karpov, Pavel | Raspor, Peter | Blume, Yaroslav
إنجليزي. The analysis of the quality of X-ray structures from Mycobacterium tuberculosis FtsZ proteins, which are deposited in the ProteinDataBank, gave a possibility to select a 2Q1Y (Chain A) structure as a template for future in silico research. Also several spatial models of FtsZ protein from Escherichia coli were reconstructed with on-line servers »Swiss-Model Workspace« and I-Tasser, than the most appropriate structure was selected. Basing on complex bioinformatic study, the model, which was rebuilt by SwissModel server from 2Q1Y (chain A) template, was supposed as the most significant.
اظهر المزيد [+] اقل [-]السلوفينية. Analiza struktur proteinov FtsZ z X žarki iz Mycobacterium tuberculosis deponiranih v »ProteinDataBank« je dala možnost izbora strukture 2Q1Y (veriga A) kot matrice za nadaljno in silico raziskavo. Nekaj prostorskih modelov proteina FtsZ iz bakterije Escherichia coli je bilo rekonstruiranih na on-line serverju SwissModel in I-Tasser, kateremu je sledil izbor najprimernejše strukture. Na osnovi celovite bioinformacijske preverbe kaže, da je model narejen na platformi serverja SwissModel iz matrice 2Q1Y (veriga A) najbolj sprejemljiv za uporabo.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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تم تزويد هذا السجل من قبل University of Ljubljana