Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study
2019
Lisse Angarita Dávila | Valmore Bermúdez | Daniel Aparicio | Virginia Céspedes | Ma. Escobar | Samuel Durán-Agüero | Silvana Cisternas | Jorge de Assis Costa | Diana Rojas-Gómez | Nadia Reyna | Jose López-Miranda
Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min: and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p <: 0.001). The insulin area under the curve (AUC0–180 min) (p <: 0.02) and GIP AUC (p <: 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p <: 0.05). Subjective appetite AUC was greater after ET than ONS-D (p <: 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA: isomaltulose and sucromalt may have influenced these factors.
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