Impact of Fenugreek on Milk Production in Rodent Models of Lactation Challenge
2019
Thomas Sevrin | Marie-Cécile Alexandre-Gouabau | Blandine Castellano | Audrey Aguesse | Khadija Ouguerram | Patrick Ngyuen | Dominique Darmaun | Clair-Yves Boquien
Fenugreek, a herbal remedy, has long been used as galactologue to help mothers likely to stop breastfeeding because of perceived insufficient milk production. However, few studies highlight the efficacy of fenugreek in enhancing milk production. The aims of our study were to determine whether fenugreek increased milk yield in rodent models of lactation challenge and if so, to verify the lack of adverse effects on dam and offspring metabolism. Two lactation challenges were tested: increased litter size to 12 pups in dams fed a 20% protein diet and perinatal restriction to an 8% protein diet with eight pups&rsquo: litter, with or without 1 g.kg&minus:1.day&minus:1 dietary supplementation of fenugreek, compared to control dams fed 20% protein diet with eight pups&rsquo: litters. Milk flow was measured by the deuterium oxide enrichment method, and milk composition was assessed. Lipid and glucose metabolism parameters were assessed in dam and offspring plasmas. Fenugreek increased milk production by 16% in the litter size increase challenge, resulting in an 11% increase in pup growth without deleterious effect on dam-litter metabolism. Fenugreek had no effect in the maternal protein restriction challenge. These results suggest a galactologue effect of fenugreek when mothers have no physiological difficulties in producing milk.
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