Clinical and Demographic Features of Paracoccidioidomycosis in Argentina: A Multicenter Study Analysis of 466 Cases
2023
Gustavo Giusiano | Fernanda Tracogna | Gabriela Santiso | Florencia Rojas | Fernando Messina | Vanesa Sosa | Yone Chacón | Maria de los Ángeles Sosa | Javier Mussin | María Emilia Cattana | Andrea Vazquez | Patricia Formosa | Norma Fernández | Milagros Piedrabuena | Ruth Valdez | Florencia Davalos | Mariana Fernández | Alejandra Acuña | Alejandra Aguilera | Liliana Guelfand | Javier Afeltra | Guillermo Garcia Effron | Gladys Posse | Susana Amigot | Julian Serrano | Otilia Sellares | Christian Álvarez | Gloria Pineda | Susana Carnovale | Laura Zalazar | Cristina Canteros
Information on paracoccidioidomycosis (PCM) in Argentina is fragmented and has historically been based on estimates, supported only by a series of a few reported cases. Considering the lack of global information, a national multicentric study in order to carry out a more comprehensive analysis was warranted. We present a data analysis including demographic and clinical aspects of a historical series of 466 cases recorded over 10 years (2012&ndash:2021). Patients were aged from 1 to 89 years. The general male: female (M:F) ratio was 9.5:1 with significant variation according to the age group. Interestingly, the age range 21&ndash:30 shows an M:F ratio of 2:1. Most of the cases (86%) were registered in northeast Argentina (NEA), showing hyperendemic areas in Chaco province with more than 2 cases per 10,000 inhabitants. The chronic clinical form occurred in 85.6% of cases and the acute/subacute form occurred in 14.4% of cases, but most of these juvenile type cases occurred in northwestern Argentina (NWA). In NEA, the incidence of the chronic form was 90.6%: in NWA, the acute/subacute form exceeded 37%. Diagnosis by microscopy showed 96% positivity but antibody detection displays 17% of false negatives. Tuberculosis was the most frequent comorbidity, but a diverse spectrum of bacterial, fungal, viral, parasitic, and other non-infectious comorbidities was recorded. This national multicenter registry was launched in order to better understand the current status of PCM in Argentina and shows the two endemic zones with a highly diverse epidemiology.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Multidisciplinary Digital Publishing Institute