The Preventive Effect of Theabrownin from Ya’an Tibetan Tea Against UVB-Induced Skin Photodamage in BALB/c Mice via the MAPK/NF-κB and Nrf2 Signaling Pathways
2025
Jingyi Xu | Mingji Xie | Xing Liang | Peida Luo | Xinyao Yang | Jing Zhao | Jinlin Bian | Bo Sun | Qian Tang | Xiao Du | Yao Zou | Weidong Dai | Chunlei He
Ya&rsquo:an Tibetan tea, renowned as a mysterious tea, has been used as a traditional remedy for disease prevention among ethnic minorities in the Qinghai-Tibet Plateau region, which experiences the highest levels of UVB radiation in the world, for over 1000 years. Theabrownin (TB) from Ya&rsquo:an Tibetan tea exhibits various health benefits. In this study, the preventive effects of TB on UVB-induced skin damage were investigated. The results showed that TB pretreatment significantly alleviated visible skin damage, epidermal hyperplasia, and collagen destruction in BALB/c mice. The mechanism of action involved increasing the mRNA and protein levels of Nrf2 and enhancing SOD enzyme activity, thereby reducing MDA content and improving the body&rsquo:s antioxidant capacity. TB also inhibited the protein synthesis of inflammatory factors such as TNF-&alpha:, IL-1&beta:, and IL-6, as well as the expression of NF-&kappa:B mRNA and protein, thereby reducing skin inflammation. Furthermore, it suppressed the overexpression of p38 MAPK, ERK, and AP-1 mRNA and protein, along with the downstream MMP-1 protein, to prevent collagen destruction in the skin. Additionally, TB pretreatment prevented cell apoptosis by reducing Caspase-3 overexpression. These results suggest that TB can prevent UVB-induced photodamage and exert its preventive effects in a dose-dependent manner by downregulating the MAPK/NF-&kappa:B signaling pathway while promoting the Nrf2 signaling pathway in the skin. Consequently, TB holds promising potential for future applications in skin photodamage prevention and skin health promotion.
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