Brain-blood biomarkers take a walk on the wild side: glial responses to environmental conditions and individual traits in wild frogs
2025
Lorrain-Soligon, Lea | Dubois, Christophe, J | Bichet, Coraline | Brischoux, Francois | Badaut, Jerome | Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC) ; La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols (METIS) ; École Pratique des Hautes Études (EPHE) ; Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
International audience
اظهر المزيد [+] اقل [-]إنجليزي. We investigated the use of brain Glial fibrillary acidic protein (GFAP), a cytoskeletal protein of astrocytes, that has been associated with brain disorders in clinical studies, as a biomarker of environmental conditions and individual traits in wildlife. In a wild amphibian, plasmatic GFAP-levels were correlated with the salinity of ponds, immune markers and size for males. GFAP-levels were correlated with body condition for both sexes. Interestingly, captivity induced transient increase of plasmatic-GFAP levels, probably due to stress. In our study, we demonstrate that plasmatic-GFAP levels may represent an excellent brain biomarker of its plasticity to environmental conditions, physiological traits, and stress responses in wildlife.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique