Comprehensive Intrinsic Disorder Analysis of 6108 Viral Proteomes: From the Extent of Intrinsic Disorder Penetrance to Functional Annotation of Disordered Viral Proteins
2021
Kumar, Naveen | Kaushik, Rahul | Tennakoon, Chandana | Uversky, Vladimir, N | Longhi, Sonia | Zhang, Kam, y J | Bhatia, Sandeep | RIKEN Center for Biosystems Dynamics Research [Kobe] (RIKEN BDR) ; RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN) | University of South Florida [Tampa] (USF) | Institute for Biological Instrumentation ; Russian Academy of Sciences [Moscow] (RAS) | Architecture et fonction des macromolécules biologiques (AFMB) ; Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
International audience
اظهر المزيد [+] اقل [-]إنجليزي. Much of our understanding of proteins and proteomes comes from the traditional protein structure-function paradigm. However, in the last two decades, both computational and experimental studies have provided evidence that a large fraction of functional proteomes across different domains of life consists of intrinsically disordered proteins thus triggering a quest to unravel and decipher protein intrinsic disorder. Unlike structured/ordered proteins, intrinsically disordered proteins/regions (IDPs/IDRs) do not possess a well-defined structure under physiological conditions, and exist as highly dynamic conformational ensembles. In spite of this peculiarity, these proteins have crucial roles in cell signaling and regulation. To date, studies on the abundance and function of IDPs/IDRs in viruses are rather limited. In order to fill this gap, we carried out an extensive and thorough bioinformatics analysis of 283,000 proteins from 6,108 reference viral proteomes. We analyzed protein intrinsic disorder from multiple perspectives, such as abundance of IDPs/IDRs across diverse virus types, their functional annotations, and subcellular localization in taxonomically divergent hosts. We show that the content of IDPs/IDRs in viral proteomes varies broadly as a function of virus genome types and
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique