Relevance. Solanum tuberosum L. – it is one of the main food crops, therefore, the study of the influence of innovative growth regulators on physiological and biochemical parameters and plant yield is very important for the agro-industrial complex.Material and methods. The research was carried out on the gray forest soil of the Orel region in the conditions of a vegetation house on the basis of the farm Stebakov V.I. in the period 2020-2021. Potato of the Nevsky variety was used as the object of the study. Treatment with growth regulators was carried out by soaking Solanum tuberosum tubers in aqueous solutions of melafene (10-6%), Energy-M (10-3%) for 8 hours. When laying the experiments, the optimal amount of nitrogen (2.3 g), phosphorus (0.7 g) and potassium (3.1 g) was introduced into the soil for potato. Was determined catalase, peroxidase activity. The amount of hydroperoxides, an intermediate product of POL, was estimated by reaction with ammonium rhodanide, the content of malonic dialdehyde by reaction with thiobarbituric acid. The experiment was carried out three times. Statistical processing of the results was carried out by the method of one-factor analysis of variance using the computer program "MS Exel".Results. Studies have shown that there is an increase in the activity of catalase and peroxidase in all variants of the experiment compared with the control in leaves, in tubers – the activity of enzymes decreases. There was a decrease in the content of malondialdehyde in all variants of the experiment compared with the control. The analysis of the final productivity revealed that the total number of tubers on one bush of the potato in the variants with growth regulators changes slightly, while the mass of tubers increases, so the variant with the growth regulator melafen increased this indicator by 37% compared to the control.