Relevance. Garlic is one of the most popular agricultural crops characterized by high nutritional value and unique chemical composition providing significant beneficial effect on human health.Methods. The review summarizes the most significant publications on garlic biochemical composition, utilization in medicine, human nutrition and agriculture for a period from 1988 to 2024 with the predominant utilization of Scopus and WoS publications.Results. The diversity of garlic processing products (fresh, dry powder, ‘Green' garlic, Laba garlic, garlic essential oil macerate, ethanolic extract (‘aged garlic extract' AGE) and black garlic) provides the diversity of biochemical composition and the direction of biological effect. The possibility to utilize both garlic bulbs, leaves, stems and peel in medicine and agriculture (for yield and stress resistance improvement) are the most important factors for successful waste free production and wide utilization of garlic.