Twenty one wheat hybrids and their seven parental genotypes were evaluated in the research farm of the Faculty of Agriculture, Ain shams University, Shoubra El-khema, Cairo, Egypt, in 2016/2017 growing season. The genetic analysis was conducted using Griffing (1956), Method 2, model 1).                 Significant differences among parent genotypes and their 21 crosses for all the studied traits (days to 50% heading, days to maturity, flag leaf area, plant height, number of spikes/ plant, spike length, number of spikelets/ spike, number of kernels/ spike, 1000-kernel weight and grain yield/ plant) were detected. This indicated that, variability exists among these populations may increase the chance appearance of good new combination that can be isolated in the succeeding generations. Parents versus crosses mean squares as an indication for average heterosis over all crosses were significant for all studied traits.                 Mean squares of general (GCA) and specific (SCA) combining abilities were significant for all studied traits except spike length trait for SCA which was insignificant. GCA/SCA ratios were more than unity for all studied traits, which indicating that the additive type of gene action is of great importance in the inheritance of these traits. Heterosis over the better parents showed that, the best hybrids were Gemmiza 9xGiza 168, Sakha 93x Giza, 168, Sakha 94x Jawahir-14, Sakha 94x Bob white, Giza 168xAcsad 925 and Jawahir-14x Bob white for grain yield/ plant trait and some of the other studied traits. The best general combiner parents were Sakha 94, Jawahir-14 and Bob white for grain yield/ plant trait and some of the other studied traits. The best SCA hybrids were Gemmiza 9x Sakha 93, Gemmiza 9x Giza 168, Sakha 93x Jawahir-14, Sakha 94xJawahir-14, Sakha 94x Acsad 925, Sakha 94xBob white, Giza 168x Jawahir-14, Giza 168x Acsad 925, Jawahir-14x Bob white and Acsad 925x Bob white for grain yield/ plant trait and some of the other studied traits. These result could be used in wheat breeding programs.