Treatments by three herbicides named; Methabenzthiazuron, Isoprotoron and Chlorotoluron to control Italian ryegrass growing with barley during pre-emergence stage were investigated. Results showed that clear damage have been occurred by the three chemicals without prominent effect on barley plants. Italian ryegrass was controlled significantly (p<0.01) by all of the herbicides used but the three herbicides differed significantly (p<0.05) in their effects. Chlorotoluron gave effective control of Lolium multiflorum at dose of 2kg a.i/ha and slight damage on barley was observed. Isoproturon and methabenzthiazuron were less effective as more than 40% of Lolium multiflorum survived at different doses while barley was not affected significantly.