Persistence Vs degradation behavior of insecticide imidacloprid (35% SC) and fungicide myclobutanil (24% EC) in/on grape (leaves and fruits) and surrounding soil under canopy were investigated under field conditions. Leaves, fruits and soil samples were collected at 2 hours to 21 days after application at the recommended rate. QuEChERS method was used for extraction and clean-up and analyzed using HPLC and GC for imidacloprid and myclobutanil, respectively .The initial residue deposits, degradation percentages and/or, the parameters (RL50 and RL90) and Pre Harvest Intervals (PHIs) of the targeted pesticides were the criteria of concern. Results revealed that, grape leaves retained higher initial amounts than fruits by about 5.0 7 and 1.34 times for imidacloprid and myclobutanil, respectively. As for RL50, RL90 and PHIs values, imidacloprid showed 4.12 ,13.42 and 21.95 days and 5.13 ,13.41 and 11.96 days on grape leaves and fruit, respectively. The corresponding calculated values were 4.71, 9.38 and 16.31days and 1.97, 9.14 and 14.90 days for myclobutanil on the same targeted samples, respectively. In addition, the grape fruits could be consumed safely after 12 and 15 days of treatment with imidacloprid and myclobutanil, respectively. On the other hand , results indicated that the residue half life (RL50) values for the same targeted pesticides in soil  were 11.56 and 15.74 days, respectively. In general, myclobutanil residues in soil recorded higher persistence levels than higher imidacloprid and on the contrary it showed less persistence in/on grape leaves and fruits.