Steroid hormones (H) and tetracycline antibiotics (T) are considered two important classes of veterinary therapeutic agents administrated to livestock for different purposes that have been detected for many environmental matrices in wide concentrations range. The effect of progesterone (Pro), androstenedione (4-AD), androstadienedione (1,4-AD) and tetracycline antibiotics namely oxytetracycline (OTC), chlortetracycline (CTC) and tetracycline (TC) on arugula plants (Eruca sativa) growth and biochemical composition was investigated. Compost and potassium permanganate were applied to minimizing the negative effect of veterinary therapeutic agentson plant. A pot experiment was conducted at the greenhouse of Agricultural Research Center (ARC) at Giza Governorate, Egypt. Soil fortified with 2 mg kg-1 of H and Ttarget compounds individually and combined was used to study their effect on chlorophyll, proline, catalase (CAT), and peroxidase (POD) activities as antioxidant enzyme and plant growth. Under this experiment conditions; the obtained results showed that veterinary therapeutic agents caused increased the content of proline, however chlorophyll content was increased as a result of H application and decreased with T application. Both CAT and POD activities were increased, especially with the combined mixture application. Potassium permanganate or compost can be used for remediation procedures in veterinary therapeutic agentscontaminated soils.