Theranekron®is commercially available, alcoholic extract of the tarantula cubensis(brown spider).Ten healthy thoroughbred mare racehorses were used at the present study. Blood samples were taken 30 minutes before and 8, 24, 48, 72 and 168h aftersubcutaneousadministration of 10ml Theranekron (1mg/48kg or 0.02mg/kgbw) via a jugular catheter. The results of this study showed that sampling time had a significant effects on the amount of PCV, hemoglobin concentration, RBC number, total protein, albumin, glucose, cholesterol, BUN, creatinine, bilirubin, activity of ALT, and ALP (p0.05). In conclusion, most of the observed changes in hematological and serum biochemical parameters were statistically and not clinically significant. Thus it seems that administration of Theranekron has no adverse reaction in experimental horses.

Borreliosis is a bacterial zoonosis transmitted by arthropods. The infection is more common in dogs than other domestic animals. A one-month-old puppy with fever, jaundice and digestion disorder was referred to Small Animal Hospital. Laboratory results included severely regenerative anemia, neutrophilia, thrombocytopenia, strong spirochetemia and significant changes in serum proteins. The attempt to isolate the bacteria in animal laboratory failed. The infection was treated using the antibiotics and the animal completely recovered.

Lipid rich carcinoma is rare in dog and women and is characterized by cells that have an abundant foamy cytoplasm. A 10 year old, mix breed female dog suffered two subcutaneous masses in ventral abdomen was referred to surgery department of veterinary hospital of Ahvaz Shahid Chamran University. Surgical excision and microscopic examination of masses were done. After grading by Elston and Ellis method, istochemical staining was performed such as PAS, Cong red and Oil Red O.Immunohistochemical detection of pKi67, P53, cerbB2 and factor VIII – related antigen were carried out.icroscopically, the masses were two parts; first compose of big cells with vacuolated cytoplasm and euchromatin nuclei and second part cells with scant cytoplasm and pleomorphic nuclei and obvious membrane. Grade of tumor was Grade III, poorly differentiated. Positive reaction was seen in vacuolated cytoplasm for Oil Red O. Neoplastic cells of lipid rich area demonstrated intense immunoreactivity for pKi67. All tumor cells lacked p53 and c-erbB2. This is the first report of coincidence of lipid rich carcinoma and solid carcinoma in a dog with description of histopathologic and immunohistochemical characteristics.

Dirofilaria immitis is a filariid worm which typically lives as adult in the right ventricle of the heart and the pulmonary arteries of the dog, causing the canine heartworm disease.Therapy of canine dirofilariosis due to Dirofilaria immitis is indicated for dogs suffering from clinical signs of the disease (such as chronic cough). The present paper describes diagnostic and treatment features of a D. immitis affected dog in Ahvaz district, Southwest of Iran. The dog had coughing, tachypnea, labored breathing, panting, hind limb edema,weakness, and exercise intolerance, at the time of referral. Auscultation revealed grade III/VI systolic murmur over the left apex of the heart. Giemsa stained blood smears containing microfilaria was morphologically identified as D. immitis. CBC revealed an inflammatory leukogram and mild anemia. Combined therapy with ivermectin (440 μg/kg as single dose),levamisol (10 mg/kg q 24 h for 10 days) and aspirin (10 mg/kg q 12 h for 10 days), during 2 stages, was effective. The number of microfilaria dropped from 1250±50/ml blood pretreatment to 150±10/ml (following the first treatment stage, after 10 days) and reached 0 a day after the second treatment. The animal remained negative regarding D. immitis microfilaremia during a follow-up period of 180 days. This record confirms the efficacy of ivermectin with levamisol and aspirin in the treatment of adult heartworm infection in a dog.

Q fever is an important zoonotic disease caused by infection with Coxiella burnetii. Limited information is available concerning theseroprevalence of Coxiella burnetii in Iran.A serological survey was conducted to describe the eroepidemiology of Coxiellaburnetii infection in dairy cattle in Khorasan Razavi province located in northeast of Iran. 246 dairy cattle from 19 commercial dairy herds that were distributed in 9 counties were selected. Blood samples were assayed for antibody to Coxiella burnetii using CHEKIT Q fever ELISA kit.Seroprevalence of Coxiella burnetii at animal and herd level was 22.3 (95% CI: 17.1-27.6) and 78.9 (95% CI: 60-97) percent, respectively. Coxiella burnetii was distributed all over the province. The proportion of seropositive animals ranged from 0 - 62.5%in the studied herds and it was different significantly in various regions (P=0.001).Parity and herd size were not associated with seroprevalence. High prevalence of antibody against Coxiella burnetii in the cattle population of the study area implies zoonotic and economic importance. More investigations on the other reservoirs and human (especially at risk population) are necessary to make epidemiologic feature of Coxiellosis clear.