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Expression of CD133, CD44, CK7, and OCT4 in Animal Cancers
2013
Park, J.H., Chungnam National University, Daejeon, Republic of Korea | Cho, E.S., Chungnam National University, Daejeon, Republic of Korea | Ryu, S.Y., Chungnam National University, Daejeon, Republic of Korea | Jung, J.Y., Chungnam National University, Daejeon, Republic of Korea | Son, H.Y., Chungnam National University, Daejeon, Republic of Korea
Cancers are mainly sustained by a small pool of neoplastic cells, known as cancer stem cells or tumorinitiating cells. These cells possess the ability to self-renew and proliferate, and are thus able to form the tumor. In the present study cells that correspond to cancer stem cells in mammary and liver cancers in animals were identified by the expression of CD133, CD44, CK7, and OCT4 using immunochemistry. As a result, we found with CD133+ and CD44+ cancer stem cell-like phenotypes in mouse and canine hepatocellular carcinoma and canine mammary gland tumors. However, CK7+ and OCT4+ cells were not identified in animal mammary and liver cancer. CD133+ and CD44+ cells are wellknown stem cell lines and play key roles in development and metastasis in human cancer. These findings suggest that cancer stem cells are involved in animal tumorigenesis and may provide insight into mechanisms in cancer development as well as cancer diagnostics.
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