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Ectopic migration of Dirofilaria immitis in a Eurasian otter (Lutra lutra) in Korea
2018
Jung, J.Y., Animal and Plant Quarantine Agency, Gimcheon, Republic of Korea | Lee, K., Animal and Plant Quarantine Agency, Gimcheon, Republic of Korea | Seo, H.J., Animal and Plant Quarantine Agency, Gimcheon, Republic of Korea | Cho, Y.S., Animal and Plant Quarantine Agency, Gimcheon, Republic of Korea | Kim, Y.D., Onnury Animal Clinic, Suncheon, Republic of Korea | Kim, J.H., Animal and Plant Quarantine Agency, Gimcheon, Republic of Korea | So, B.J., Animal and Plant Quarantine Agency, Gimcheon, Republic of Korea | Choi, E.J., Animal and Plant Quarantine Agency, Gimcheon, Republic of Korea
An 8-year-old female Eurasian otter (Lutra lutra) reared in a wetland center, died 2 h after sudden onset of astasia and dyspnea despite medical treatment. Gross examination of internal organs revealed 10 adult filarioid nematodes in the right ventricle of the heart and three between the left and right cerebral hemispheres. All nematodes were identified as Dirofilaria immitis by direct microscopy and polymerase chain reaction assay. Histopathological observation revealed multifocal hemorrhage in the cerebral subarachnoid space and focal necrosis with hemorrhage in the cerebellar parenchyma. Although rare, veterinarians should consider cerebral dirofilariasis as a differential diagnosis in unexplained neurological cases.
اظهر المزيد [+] اقل [-]Evaluation of the lateral ventricle using MRI in normal micropigs
2011
Choi, M.H., Seoul National University, Seoul, Republic of Korea | Lee, N.S., Seoul National University, Seoul, Republic of Korea | Yi, K.J., Seoul National University, Seoul, Republic of Korea | Kim, J.Y., Seoul National University, Seoul, Republic of Korea | Choi, M.C., Seoul National University, Seoul, Republic of Korea
This study was undertaken to assess the lateral ventricle, which was some portion of brain and related to congenital anomalies, from 1, 2, 4, and 8 months of age in healthy micropigs. They were induced general anesthesia and performed magnetic resonance imaging (MRI) with a 0.3 Tesla magnet. Each age group was evaluated by three subjects such as lateral ventricular volume, ventricular volume ratio and asymmetry. T1 weighted transverse images were acquired for calculation of lateral ventricular and corresponding brain parenchyma areas. The ratio of bilateral ventricle areas used to analyze the asymmetry. The mean ventricular volumes of each month were 676.74 ± 25.58 ㎣ (1 month-old), 630.64 ± 143.84 ㎣ (2 month-old), 992.12 ± 106.03 ㎣ (4 month-old) and 1172.62 ± 237.57 ㎣ (8 month-old), respectively. The ventricular volume ratio was the smallest at 2 month-old and re-increased from that age. The ratio was significantly different between 2 month-old and other age groups (p less than 0.05). The value of bilateral area ratio showed within 1.5 in all experimental animals. Consequently the lateral ventricle showed a positive correlation with aging and symmetric shapes in both sides. The developmental pattern of the lateral ventricle provides basic data in micropigs as an experimental animal model for physiological and neurosurgical approach.
اظهر المزيد [+] اقل [-]Cerebellar maturation ratio of forebrain and brainstem at magnetic resonance imaging in the micropig
2012
Yi, K.J., Seoul National University, Seoul, Republic of Korea | Kim, J.Y., Seoul National University, Seoul, Republic of Korea | Lee, N.S., Seoul National University, Seoul, Republic of Korea | Choi, M.H., Seoul National University, Seoul, Republic of Korea | Yoon, J.H., Seoul National University, Seoul, Republic of Korea | Choi, M.C., Seoul National University, Seoul, Republic of Korea
The study of pigs as a human disease model has been conducted in neuroscience. But the morphological development of pig brain by using MRI is rare. The purpose of this study is to determine whether cerebellum maintains consistent proportion to other brain regions in aging. Clinically healthy sixteen micropigs, 1, 2, 4, and 8 months were studied. The micropigs were anesthetized with isoflorane. MRI was acquired using a 0.3T system. To figure out development of ratio that allowed identification of normal cerebellum size, we measured the area of the cerebellum, brainstem, and forebrain from the mid-sagittal brain images on T1W. Mid-sagittal cross-sectional area (CSA) of total brain, forebrain, brainstem, and cerebellum were expressed as absolute values and also as percentages which were compared between the four age groups of micropigs for the purpose to define the effect of age on brain morphometry. It was found that there was not a significant difference in the percentage of the brain occupied by an individual region between groups although the absolute CSA differed significantly among age groups. There was no effect of age on the ratio between the cerebellum and total brain in 4 age groups. The normal size of cerebellum changes during brain development maintained a consistent ratio to other brain regions in normal micropigs. The ratio of CSA quantified on the mid-sagittal MR images offers a suitable method to detect presence of cerebellar anomalies in micropigs.
اظهر المزيد [+] اقل [-]Shiga-like toxin-2-producing Escherichia coli 0157 : H7 infection in gnotobiotic piglets : protection against brain vascular lesions with SLT-2 antiserum
1993
Chae, C.H. | Moxley, R.A. (Nebraska University, Lincoln (USA). Veterinary Diagnostic Center)