Production examination of efficiency of concentrated vaccine against swine erysipelas from matrix Konev of trial series, control of its immunizing power and production experiments of biological preparation were realized in the conditions of the Republic of Belarus. Research results showed that the presented vaccine had more expressed immunogenic properties in comparison with its production analogue and provided piglets protection against infection. There was analyzed the immunological efficiency of the vaccine: determination of quantity of erythrocytes; leukocytes; content of hemoglobin, level of lysozyme activity, bacterial growth-inhibitory activity, blood serum, phagocytic activity, neutrophilic leukocytes, content of total protein and protein fractions, titre of erysipelas antibodies, and preventive properties of blood serum. Efficiency of biological preparation was determined on the basis of analysis of disease incidence rate, loss of immunized swine caused by swine erysipelas

Investigation of influence of water improved by potassium permanganate solution on welfare and productivity of piglets was realized in the conditions of swine breeding complex in the Republic of Belarus. In the experiment there were used 2 groups of 30-day old piglets. In course of 75 days of experiment the running water of pig complex was used for watering of piglets of control group. Piglets from the experimental group were given water with addition of 0,1% solution of potassium permanganate. Analysis of obtained results showed that water with potassium permanganate promoted the increasing of natural resistance of piglets. At the same time there was stated the increasing of lysozyme and bacterial activityin blood serum. Application of improved water promoted the increasing hemoglobin on 4,8-4,5%, erythrocytes - on 2,9-4,2% in comparison with control. Content of total protein increased on 2,2-2,8% in the experimental groups, lisozyme activity - 6,9-7,0% and bacterial activity - on 5-6,9%. Application of improved water did not influence the glucose and potassium concentration in blood. In the experimental group there was stated the increased lipid concentration on 3,1-6%, cholesterol - on 4,4-6,3%, potassium level - on 2,5-4,5%, phosphorus - on 0,7-5,3%, sodium - on 1,4-3,8%. Application of water with КMnО4 increased average daily weight gain on 5,2-4,2%

Influence of monocalcium phosphate on natural resistance and clinical indexes of blood of breeding bull calves of white-and-black breed was realized in the conditions of the Republic of Belarus. Bull calves of the first (control) group in the composition of their main ration were fed with mixed fodder K-66-b, hay, green mass and as a balanced phosphoric-potassium additive they were fed with8 grams of defluorinated phosphate per 1 kg of mixed feed. Bulls of the second, third and fourth experimental groups in combination with the standard ration instead of difluoridated phosphate were fed with 5; 10; and 15 grams monocalcium phosphate per 1 kg of combined feed, respectively. Research results showed that application of fodder monocalcium phosphate in addition to the main ration made it possible to increase calcium and phosphorus content in blood of experimental bull calves. In the control group phosphorous content was 2,17 micromole, in the experimental groups – 2,40-2,78 micromole; calcium content – 2,50 and 2,58-2,88 micromole, respectively. The analyzed additive rendered positive effect on protein exchange, increased the natural resistance, bacterial growth-inhibitory activity in blood serum in the third, fourth and second groups on 50,3%, 42,5%, and 40,3%, respectively; lysozyme activity – on 46,0%, 39,2%, and 32,3%, respectively; phagocytic activity of leukocytes – on 21,9%, 25%, and 19,1%

The purpose of the research was establishment of hepatic diseases spread in cattle fattening. Trials were conducted with total number of hybrids IV-V generation of black-motley heifer with pedigree Hereford bulls. It has been established the wide spread (22,4%) of hepatic pathology. The leading place among all hepatic pathologies belongs to fatty hepatosis (13,4%) with weakly expressed symptoms, decrease of serum protein level, albumin, glucose and increase of bilirubin, globulins, hepatic enzymes and strong pathology-anatomical and histological manifestations. In the tabular form results of histologic research of liver, some biochemical indicators of blood of healthy and sick animals (M +/- m), the clinical symptoms revealed during the various periods are resulted | Целью исследований являлось изучение структуры и установление широты распространения болезней печени у крупного рогатого скота на откорме. Опыты проведены на широком поголовье помесей IV-V поколения тёлок чёрно-пёстрой породы с племенными быками герефордской породы. Установлено широкое (22,4%) распространение гепатопатий. Ведущее место среди различных форм поражения печени принадлежит жировому гепатозу - 13,4%, морфофункцинальный профиль которого определяется слабо выраженными клиническими симптомами, уменьшением уровня общего белка, альбуминов, глюкозы, повышением концентрации билирубина, активности гепатоспецифических ферментов, а также всех фракций глобулинов, яркой и характерной патологоанатомической и гистологической картиной. В табличной форме приведены результаты гистологического исследования печени, некоторые биохимические показатели крови здоровых и больных животных (M +/- m), клинические симптомы, выявленные в различные периоды

As a result of realized in the conditions of the Republic of Belarus research it was revealed that application of immunostimulative drugs of sodium thyosulphate and vitamin С (ascorbic acid) in combination with a vaccine against salmonellosis, pasteurellosis and streptococcosis of pigs promoted the statistically authentic increasing of leukocytes, absolute quantity of T- and B-lymphocytes content in peripheral blood. Also, it promoted the activation of phagocytic activity and digested ability of neutrophils; activization of mieloblastic hemopoiesis and decreasing of erythrocytopoiesis; activization of morphological reactions in a tissue at a place of administration of the vaccine, lymphatic nodules and spleen. | Проведенные исследования показали, что применение иммуностимуляторов натрия тиосульфата и витамина С с вакциной против сальмонеллеза, пастереллеза и стрептококкоза свиней способствует статистически достоверному повышению в периферической крови содержания лейкоцитов, абсолютного количества Т- и В-лимфоцитов, активизации фагоцитарной активности и перевариваемой способности нейтрофилов; активизации миелобластического кроветворения и снижению эритропоэза; активизации морфологических реакций в ткани на месте введения вакцины, лимфоузлах и селезенке.

Research on determination of changes of morphological and biochemical blood indexes of sheep with fasciolosis after application of the drug Klozantsid (menizol 20%, produced in the Republic of Belarus) was carried out. The research realized in the conditions of the Scientific and Research Institute of Applied Veterinary Medicine and Biotechnology of the Vitebsk State Academy of Veterinary Medicine. In course of the experiment there were used sheep of Romanovskaya breed at the age from 1,5 till 5 years which were spontaneously infected with fasciola. The experimental animals were administrated with the examined antihelminthic preparation. It was found out that after administration of the preparation there was stated the restoration of a level of erythrocytes, haemoglobin, leukocytes, enzymes, proteins and other blood indexes. Klozantsid did not render toxic influence on studied animals. | Проведены исследования по выяснению изменений морфологических и биохимических показателей крови у овец с фасциолёзной инвазией при применении препарата Клозанцид. Исследования проводили в условиях клиники и лаборатории кафедры паразитологии и инвазионных болезней, лаборатории кафедры клинической диагностики, научно-исследовательского института прикладной ветеринарной медицины и биотехнологии учреждения образования «Витебская ордена «Знак Почёта» государственная академия ветеринарной медицины». Объектом исследования являлись овцы романовской породы в возрасте от 1,5 до 5 лет, спонтанно зараженные фасциолами, которым применяли испытуемый препарат, обладающий антигельминтными свойствами. При этом выяснено, что после введения препарата происходит восстановление уровня эритроцитов, гемоглобина, лейкоцитов, ферментов, белков и других показателей. Клозанцид не оказывал токсического влияния на организм животного.

In the conditions of the Republic of Belarus there was determined the parasitizing influence of Oesophagostomum and their larvae on a metabolism of experimentally infested animals. In course of the study there were generated experimental and control groups of two-month old piglets. Animals of the experimental group were infested in a dose of 15000 invasion larvae per one kg of body weight. Animals of the control group were not infested. Infestation was realized through a mouth with invasion larvae with wet forage. Invasion larvae received by cultivation of excrement tests from infested pigs at temperature of 24 deg C. As a result of the realized research it was established, that Oesophagostomum invasion rendered a substantial influence on the experimental animals. At bimestrious pigs after the experimental infection with Oesophagostomum larvae there were stated the following changes: the disease on 4-30th day was characterized by frustration of function of a gastroenteric path - diarrhea, fever, anaemia, and in the subsequent - stagnation and juvenilism of animals. Oesophagostomum in a host organism caused the pathological changes of haemotological and biochemical blood value which were expressed in quantity decrease of erythrocytes, concentration of haemoglobin, leucocytosis. Eosinophilia was observed in a leukogram. In blood serum there was stated the lowering of crude protein and its fractions content; gradually, but authentically there was noted the increasing of activity serum glutamic oxalacetic transaminase and glutamic-pyruvic transaminase. Bactericidal and lysozymic activity of blood serum decreased. Activity of alkaline phosphatase increased.

In the conditions of the Republic of Belarus there was studied the influence of herbal infusion, tincture, liquid and dry extracts of elecampane (Inula helenium) on morphological and biochemical indexes of pig blood. In course of the study it was established, that preparative forms of elecampane stimulated the formation of blood corpuscle, and also increased of the hemoglobin level in blood of pigs. Administration of elecampane preparations did not cause any authentic changes in blood leukogram of swine; all indicators were within normal limits. Elecampane preparations did not cause changes on the part of biochemical blood indexes of and did not influence the activity of enzymes. Research results showed that herbal infusion, tincture, liquid and dry extracts of elecampane did not render negative influence on swine.

In the conditions of the Republic of Belarus there was realized an experimental study of a new method treatment of calves diseased with abomasoenteritis by means of application of a preparation Ranitidin. As a result of realized research it was established that the preparation had an expressed therapeutic activity. Inclusion of Ranitidin preparation into the complex therapeutic regimen of calves sick with abomasoenteritis with the enteral feeding once in day in a dose of 0,15 g promoted the reduction of duration and decrease in severity of the disease. There were presented the results of biochemical blood indicators in trial and control groups of calves, haematologic indices in trial and control groups of calves prior to the beginning of experiment and in the end of the test.

In the conditions of the Republic of Belarus there was determined of a dose of input and efficiency of feeding with rape oil cake and protein meal produced on the basis of a new rape (Brassica napus) variety Yavar as a part of a mixed fodder KR-2 in diets of young stock of cattle. Rape oil cake and protein meal with the content of 1,4-1,9% glucosinolates and 27-30 mcM per 1 kg of a dry matter of erucidic acid can be included into composition of the mixed fodder КR-2 for bull calves in a dose up to 20% on weight. Feeding with the mixed fodders КR-2 with inclusion of rape oil cake and protein meal made it possible to receive daily average weight gain of calves at a level of 827-906 gram at expenses of forages of 5,4-5,9 forage units per 1 kilogram of a weight gain. It was caused by cheaper rape forages. In course of the study there was analyzed the chemical composition of rape oil cake and protein meal; indexes of rumen digestion of experimental bull calves; morphological and biochemical blood structure; changes of body weight; daily average weight gain and expenses for forages.