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Intravenous administration of allogeneic Wharton jelly-derived mesenchymal stem cells for treatment of dogs with congestive heart failure secondary to myxomatous mitral valve disease
2021
Yang, Vicky K. | Meola, Dawn M. | Davis, Airiel | Barton, Bruce | Hoffman, Andrew M.
OBJECTIVE To evaluate whether mesenchymal stem cells (MSCs) can be safely administered IV to dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD) to improve cardiac function and prolong survival time. ANIMALS 10 client-owned dogs with CHF secondary to MMVD. PROCEDURES Dogs with an initial episode of CHF secondary to MMVD were enrolled in a double-blind, placebo-controlled clinical trial. Five dogs in the MSC group received allogeneic Wharton jelly-derived MSCs (2 × 106 cells/kg, IV), and 5 dogs in the placebo group received a 1% solution of autologous serum (IV) for 3 injections 3 weeks apart. Cell-release criteria included trilineage differentiation, expression of CD44 and CD90 and not CD34 and major histocompatability complex class II, normal karyotype, and absence of contamination by pathogenic microorganisms. Patients were followed for 6 months or until death or euthanasia. Echocardiographic data, ECG findings, serum cardiac biomarker concentrations, CBC, and serum biochemical analysis results were obtained prior to and 4 hours after the first injection and every 3 months after the final injection. RESULTS Lymphocyte and eosinophil counts decreased significantly 4 hours after injection, and monocytes decreased significantly only in dogs that received an MSC injection. No significant differences were seen in the echocardiographic variables, ECG results, serum cardiac biomarker concentrations, survival time, and time to first diuretic drug dosage escalation between the 2 groups. CONCLUSIONS AND CLINICAL RELEVANCE This study showed that MSCs can be easily collected from canine Wharton jelly as an allogeneic source of MSCs and can be safely delivered IV to dogs with CHF secondary to MMVD.
اظهر المزيد [+] اقل [-]Impact of meloxicam on respiratory virus titers and health outcomes when administered concurrently with a modified live respiratory vaccine in abruptly weaned beef steers
2021
Homerosky, Elizabeth R. | Jelinski, Michael J. | Dorin, Craig
Abruptly weaned crossbred steer calves (N = 271) were used in a randomized, blinded 2-arm clinical trial to assess the impact of a long-acting non-steroidal anti-inflammatory drug on bovine herpesvirus type 1, bovine respiratory syncytial virus, parainfluenza virus type 3, and coronavirus titers and health outcomes when administered concurrently with a modified live respiratory vaccine upon arrival at a feedlot. Treatment groups included a control (saline; n = 135) and an experimental group (injectable meloxicam; n = 136). Viral antibody titers and body weight were measured on arrival, day 7, and day 21, along with a final weight on day 45. Body weight and antibody titers for all viruses increased over time (P < 0.001); however, there were no differences by treatment group or a significant group × time interaction when evaluated using repeated measures analysis of variance. Interestingly, the use of meloxicam was associated with increased treatment risk (P < 0.05). In conclusion, the administration of meloxicam may adversely affect health; however, a decreased vaccine response is likely not a contributing factor.
اظهر المزيد [+] اقل [-]Applied anatomy to the Gurcu goat´s mandible in Kafkas and its clinical significance in regional anesthesia
2021
Dalga, Semine
This study was designed to provide important clinical signs for tracking nerves in the mandible during regional anesthesia in Gurcu goats. Materials and methods: The study was conducted on the mandible bones of ten adult Gurcu goats of both sex (five male and five female). The mandible bone samples of naturally dead Gurcu goat were collected from Kafkas University veterinary faculty education, research, and application farm and processed as per the standard maceration technique. Altogether, 16 measurements were taken in the mandible bones of Gurcu goats by using a digital caliper and the results were expressed as mean and standard deviation.The obtained parameters from the present study can be useful for an extraoral and intraoral approach for nerve block of mental and mandibular nerve in the mandibular regions of Gurcu goat. According to results the mandibular length and height were 158.86±10.37 mm, 89.38±5.81 mm, in females and 198.93±3.85 mm, 114.5±7.29 mm, in males of Gurcu goats, respectively. The distance between the first inferior incisor tooth and mental foramen and to the first premolar tooth was 19.72±2.3, 19.26±0.44 mm in females, and 29.41±6.10, 21.83±1.02 mm, in males, respectively. The present study revealed that all the obtained parameters related to regional anesthesia showed a significant statistical difference (p<0.01**) between the males and females of Gurcu goat.It can be concluded from the present study that the various applied parameters of the present study are thought to assist clinicians in the administration of regional anesthesia in the lower jaw area (mandibular region) of the Gurcu goat.
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