BACKGROUND: Protection from reproductive damage is essential in chemotherapy medicines for cancer patients.OBJECTIVES: This study aims to examine the effect of curcumin on the structure of the ovary of mice after treatment with goserelin and cyclophosphamide.METHODS: One hundred and ten BALB/C mice with 3 regular consecutive periods of the estrous cycle were divided into 11 groups of 10 each. No medicine was used in the control group. The treatment groups were as follows: 1) cyclophosphamide, 2 to 5) cyclophosphamide with curcumin with a dose of 100, 200, 300, and 400 mg/kg, respectively, 6) goserelin, 7 to 10) goserelin together with curcumin with a dose 100, 200, 300, 400 mg/kg, respectively. The luteinizing hormone (LH) and follicle-stimulating hormone (FSH) of serums were evaluated using ELISA. Morphologic and morphometric of ovaries were assessed.RESULTS: The total number of follicles, primary, secondary, periantral, and antral follicles, in the goserelin and cyclophosphamide group, was significantly reduced compared with the control group (P<0.05). Cyclophosphamide and goserelin with different doses of curcumin showed a significant increase in the total number of follicles, primary, periantral, and antral follicles compared to the group treated with cyclophosphamide and goserelin alone (P<0.05). Curcumin (200, 300, and 400 mg/kg) and cyclophosphamide, compared to the cyclophosphamide group, significantly increased the quality of zona pellucida (P<0.05). Cyclophosphamide and goserelin caused a significant decrease in FSH and LH (P<0.05). Cyclophosphamide with different doses of curcumin showed a significant increase in LH compared to the group treated with cyclophosphamide alone (P<0.05). Goserelin with a 400 mg/kg curcumin dose significantly increased LH compared to goserelin alone (P<0.05). The amount of FSH in the cyclophosphamide groups with curcumin increased compared considerably to cyclophosphamide alone (P<0.05). The groups of goserelin with curcumin showed a significant increase in FSH compared to those of goserelin alone (P<0.05).CONCLUSIONS: Curcumin can protect the reproductive system of mice from the damage caused by the administration of cyclophosphamide and goserelin.

BACKGROUND: In the past decades, medicinal plants were used to enhance the specific and non-specific defense mechanism and to increase resistance to disease. OBJECTIVES: This study was performed to evaluate the effect of Curcuma longa L. on the hematological factors of Huso huso. METHODS: In this study, 90 beluga with average weight of 2.403± 0.006 Kg were kept on Shahid Rajai reproduction, culture and rehabilitation of sturgeon for 20 days. This number of fish were distributed in the three groups with the names curcumin, control (+) and control (-) with three replicates. After one week adaptation with experimental environment fish were injected intraperitoneally. In curcumin group 400 mg/kgbw curcumin extract at the maximum volume of 0.5 ml was used. In control (+)and in control (-) without injection 0.5 ml of physiological serum was kept just to check fish experimental conditions. Blood was taken at 0, 3, 6, 9 and 12 days post injection. RESULTS: The results of this study showed that the amount of red blood cells, white blood cells, hematocrit, hemoglobin and blood indices such as MCV, MCH, MCHC in the curcumin group was higher  than the control group (control (+) and control (-)). CONCLUSIONS: The result of this study showed that use of curcumin in beluga has high impact on increasing Hematology parameters.

Curcuma longa rhizome is the source of turmeric. Curcumin exhibits some encouraging antiparasitic properties in helminths. The purpose of this investigation was to determine the ovicidal and larvicidal activities of curcumin in Toxocara canis eggs in vitro. Curcumin dilutions (36.8 mg/ml, 18.4 mg/ml and 3.6 mg/ml) were prepared by adding RPMI-1640. The eggs and hatched infective-stage larvae were incubated with curcumin dilutions for 6, 12 or 24 hours. The ovicidal activity was evaluated after 28 days. Larvicidal activity was assessed after completing each incubation time. In the present study, no changes in the eggshell structure were observed in all curcumin groups. The lowest embryogenesis rate (75%) was observed only at the highest curcumin dilution (36.8 mg/ml) at the 12- and 24-hour incubations, but the difference was not found statistically significant. No significant larvicidal effect of curcumin was detected. The percentage of moving larvae was 80% at 12 hours and 76% at 24 hours in the highest curcumin dilution (36.8 mg/ml). T. canis larvae survived in RPMI-1640 for four days after being incubated with 36.8 mg/ml curcumin for 24 hours. However, the untreated larvae were still active at this time. Further studies focusing on the migration of T. canis infective larvae in animal models may shed light on the effect of curcumin, which is rapidly metabolized in the body and absorbed at low levels from the intestine, on the migrating larva.

The present study was carried out to evaluate the effect of curcumin on lipid peroxidation and antioxidant levels in DMBA (7, 12 Diemthyl Benanthracene) induced mammary carcinogenesis in rats. Twenty four Sprague-Dawley rats were equally distributed to control, DMBA, Tamoxifen (Standard drug) and curcumin groups. DMBA group showed significant (P&lt;0.05) increase in lipid peroxidation and antioxidants superoxide dismutase (SOD) and catalase (CAT) levels besides reduced glutathione (GSH). Whereas, curcumin and Tamoxifen treated groups did not show any significant difference in lipid peroxidation and antioxidant status when compared to the control. Selective growth advantage of tumour cells was evident in the DMBA group and curcumin was able to prevent lipid peroxidation.

Objective: This study was aimed at clinical evaluation of surgical wound healing in goats treated with ethanolic extract of turmeric (Curcuma longa) rhizomes through topical route. Materials and methods: Eighteen surgical wounds were made in nine goats. The goats were divided into three groups; Group 1 (test group) was treated with ethanolic extract of turmeric, Group 2 (standard group) was treated with Povidone iodine, and the Group 3 was kept as untreated control. Follow up information was recorded from day 0 to day 21 postoperatively. Some morphological characters such as swelling area of wound, elevation of suture line from the skin surface, width of the suture area and contraction length per week were considered to determine the healing process. Bacteriological evaluation was done by conventional bacteriological techniques, and the tissue biopsies were stained by hematoxylin and eosin stains for histopathological studies. Results: Swelling of suturing area (11.51&plusmn;0.36 mm) and elevation of suture line (2.65&plusmn;0.41 mm) were lowest in wounds treated with ethanolic extract of turmeric. In histopathological studies, it was seen that tissue debris and hemorrhages disappeared and a thin line of keratin layer reappeared on the epidermal surface of the wound treated with ethanolic extract of turmeric. Conclusion: Ethanol treated turmeric enhances wound healing process in goats. This result could help the veterinarian and the researchers to consider herbal product especially ethanolic extract of turmeric for the treatment and better healing of surgical wounds with minimal complications. [J Adv Vet Anim Res 2017; 4(2.000): 181-186]