Rosmarinus officinalis, L. (Lamiaceae) offers medicinal potential against hepatotoxicity and nephrotoxicity Due to its antioxidant and anti-toxicity properties. The objective, of this research is to explore into the ethanol extract of Rosmarinus officianalis leaves and its efficacy against  cypremethrin induce toxicity in The liver and  The kidney of male rabbits. Forty male rabbits were employed in this experience, group one ( without exposure); rabbits received corn oil ( 1 ml) group two; rabbits oral exposure to cypermethrin with dose (66.5 mg/kg/b.w ( 1/10 of LD50) dissolved in corn oil , group three( protective group) received rosemary extract with dose 100mg/kg plus cypermethrine with dose 66.5 mg/kg/b.w., group four received rosemary extract with dose 200mg/kg plus cypermethrine with dose 66.5 mg/kg/b.w. the above doses once per day for 6 weeks respectively.In accordance with the current study's findings, liver enzyme levels significantly increased. ALT,ALSand ALP),Lipid profile (TC,TG.LDL-cand VLDL_c) and  kidney function tests  (urea, a creatinine, uric acid and blood urea, nitrogen concentrations ) but significant decrease in (Total protein and HDL_ c value  ) in the treated group with cypermethrin , .whereas the animals received rosemary extract in both dose plus cypermethrin produced notable decrease in the  levels of the vital parameters of the liver and kidneys are with  the normal level. : the current study displayed that the Rosmarinus officinalis has antitoxicity activities as seen via decreasing liver enzymes, lipid profile and kidney function tests   is accompanied by elevated the levels of  total protein .            

The present study aimed to investigate the effects of different doses of of Cypermthrin on serum acetylcholine concentration , Spinal cord and Sciatic nerve histopathology in adult rats. Fourty eight adult rats were used , they divided randomly and equally into four groups . Control group orally dosed with normal saline for 90 days . The other three groups were dosed orally with different three doses of cypermthrin , high dose ( 64 mg / kg b.w. ) intermediate dose ( 32 mg / kg b.w. ) and low dose ( 16mg / kg b.w. ). The results shows that serum acetylecholine concentrations increased significantly ( p ≤ 0.05) in rats exposed to high and intermediate dose of cypermethrine compared with control group. Whereas there were no significant difference (p ≥ 0.05) between low dose of cypermethrine and contol group . Hitopathological examination of spinal cord and Sciatic nerve revealed that there were a dose dependent increase in vaccuolation in nerves fibers to be affect larg number of nerve fiber in high dose and it affect few numbers of nerve fibers in low dose. In conclusion cypermthrin affected positively histopathological findinds of nerves fibers .

The present study was carried out during the month of January 2014 when a total of 148 dogs with history of various diseases were presented to the Campus Veterinary Hospital, Teaching Veterinary Clinical Complex, College of Veterinary Science, Rajendranagar, Hyderabad, India. Out of 148 dogs that were presented to the hospital, 48 dogs had the clinical signs of loss of hair, itching, and reduced food intake. The dogs were restless and continuously rubbed their bodies against the walls in the houses, and scratching with their legs. Clinical examination of the dogs revealed presence of alopecia, pruritus, and the formation of small crusts. All 48 dogs were treated with ivermectin by subcutaneous injection dosed at 0.02 mL/kg body weight at a weekly interval for 2 to 3 weeks. All dogs were bathed with cypermethrin shampoo weekly once for 2-3 weeks. In the present study, it was observed that ivermectin/cypermethrin combination therapy was effective for the management of tick infestation in dogs.