The present study was carried out during the month of January 2014 when a total of 148 dogs with history of various diseases were presented to the Campus Veterinary Hospital, Teaching Veterinary Clinical Complex, College of Veterinary Science, Rajendranagar, Hyderabad, India. Out of 148 dogs that were presented to the hospital, 48 dogs had the clinical signs of loss of hair, itching, and reduced food intake. The dogs were restless and continuously rubbed their bodies against the walls in the houses, and scratching with their legs. Clinical examination of the dogs revealed presence of alopecia, pruritus, and the formation of small crusts. All 48 dogs were treated with ivermectin by subcutaneous injection dosed at 0.02 mL/kg body weight at a weekly interval for 2 to 3 weeks. All dogs were bathed with cypermethrin shampoo weekly once for 2-3 weeks. In the present study, it was observed that ivermectin/cypermethrin combination therapy was effective for the management of tick infestation in dogs.

The rising occurrences of male reproductive disorders, as decreased semen (quality and quantity) and testicular cancer, are of great concern for animal production. Therefore, this study was conducted to determine the toxic impact of cypermethrin on the fertility of male rats. Other goal was using the Panax ginseng as androgenic drug for reducing the negative impact of cypermethrin poisoned rats. In the results, oral LD50 of cypermethrin in mature male rats was found to be 374.633 ±12.187 mg/kg. Based on that, thirty-two adult male rats were equally divided into four groups. Group (1) served as –ve control; group (2) treated with 0.1% Panax in feed and kept as +ve control; group (3) orally dosed 1/40 LD50 of cypermethrin; and group (4) intubated the same dose of cypermethrin and panax admixed with diet for 60 days. The results demonstrated that cypermethrin generated obvious disorders in male fertility as evidenced by a significant decrease in the blood testosterone, LH and FSH hormones, testes weights, sperm count and motility, and live sperm percentage. Sperm cell abnormalities were significantly elevated in cypermethrin poisoned rats compared. Although the group treated by cypermethrin with panax showed a lesser effect. Cypermethrin intoxication showed sever alteration in fertility indices and fetal values. Histopathological examinations on the testes, seminal vesicles, and prostate glands served as confirmation for all findings. A positive control group didn’t significantly differ as compared to a negative control. Otherwise, it recorded the best results in percentage of motile and live sperm, especially drops of sperm cell abnormalities. Results concluded that involvement with cypermethrin caused overt defects in male reproductive function, which were cured by administering the androgenic drug Panax.