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Antibacterial and therapeutic effects of a combination of Sophora flavescens and Glycyrrhiza uralensis Fischer ethanol extracts on mice infected with Streptococcus pyogenes
2014
Yu, E.A., Tongyeong National Quarantine Station, Ministry of Health & Welfare, Tongyeong, Republic of Korea | Cha, C.N., Gyeongsang National University, Jinju, Republic of Korea | Park, E.K., (Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University, Busan, Republic of Korea | Yoo, C.Y., Department of Computer Information, Gyeongnam Provincial Namhae College, Namhae, Republic of Korea | Kim, S., Gyeongsang National University, Jinju, Republic of Korea | Lee, H.J., Gyeongsang National University, Jinju, Republic of Korea
This study evaluated the antibacterial effects of a mixture of Sophorae radix and Glycyrrhiza uralensis Fischer (1 : 1) ethanol extracts (SGE) on mice infected with Streptococcus (S.) pyogenes. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of SGE necessary for antibacterial effects against S. pyogenes were 20§¡/mL. Based on the time-kill curves for S. pyogenes, SGE was effective at 4 ¡¿MIC after 16 h. On Day 12 after challenge, the survival rate of mice treated with 2.0 mg/kg SGE was 60%. In conclusion, SGE had potent in vitro and in vivo antibacterial activities against S. pyogenes.
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