Despite of presence of a wide choice of antihelminthics, in the Republic of Belarus it is still a real problem of development of preparations that provide long-term treatment and preventive maintenance efficiency against helminthosis. At the same time, helminthes and anthelminthics render the immunosuppression action. The solution of this problem can be a combined application of antihelminthics and adjuvants. There were proposed preparations Albepolis and Averpolis. Their application made it possible not only to release an organism of animals from parasites, but also to correct the state of immune system. The obtained research data confirm the available data about the immunosuppression action of parasites on an organism of animals. There was also is noted the immunosuppression action of Albendazol and Aversektin C in therapeutic doses. Albendazol possess a wide spectrum of action against trematodes, nematodes, cestodes. It interrupts the metabolism, oppresses fumarate reductase activity and adenosine triphosphate synthesis of a parasite. It proved to be low-toxic for homoiothermal animals. Albendazol rendered positove influence on growth, development and increase of cattle productivity.

In the conditions of the Republic of Belarus there was studied the antihelmintic characteristics of the preparative forms of marsh cinquefoil (Comarum palustre): herbal infusion, infusion, liquid, extract, pulvis. The research has shown that these preparative forms in the specified dozes had a rather high therapeutic efficiency against strongylatosis of gastro-intestinal tract of young ruminants. The highest therapeutic effect was rendered by a liquid extract of Comarum palustre after its administration to animals in a dose of 0,2 ml/kg twice with 24 hour interval. In this case during the strongylatoses of a gastroenteric tract the antiparasitic intensefficiency of sheep and cattle by the end of experience was 98,1% and 97,3% respectively, and antiparasitic extensefficiency was 90% for both kinds of animals. After herbal infusion application of Comarum palustre for animals (in a dose of 7 ml/kg of live weight before feeding once a day within 3 days continuously) by the end of the 14 day of the experiment made it possible to obtain intensefficiency of 70% for both animal species, and extensefficiency of 60% for sheep and 70% - at calves. Tincture application of marsh cinquefoil for animals in a dose of 1 ml/kg of live weight of twice with 24 hours interval, provided the intensefficiency of 85% for sheep and 84% - for cattle, and extensefficiency of 70% and 80%, respectively. In the conditions of application of a pulvis of marsh cinquefoil in a dose of 500 mg/kg of live weight twice with 24 hours interval, made it possible to obtain the 63,4% intensefficiency for sheep and 67,8% - for calves, and extensive efficiency - 50% and 40%, respectively.

In the conditions of the Republic of Belarus there was realized an experimental study of a new method treatment of calves diseased with abomasoenteritis by means of application of a preparation Ranitidin. As a result of realized research it was established that the preparation had an expressed therapeutic activity. Inclusion of Ranitidin preparation into the complex therapeutic regimen of calves sick with abomasoenteritis with the enteral feeding once in day in a dose of 0,15 g promoted the reduction of duration and decrease in severity of the disease. There were presented the results of biochemical blood indicators in trial and control groups of calves, haematologic indices in trial and control groups of calves prior to the beginning of experiment and in the end of the test.

In the conditions of the Republic of Belarus there were analyzed productivity indexes of sows of different families and family groups and their compatibility with male pigs of different lines of Belarusian meaty breed and Landras. On the basis of the realized research it was marked, that according to the number of piglets in a litter and multiple pregnancy distinctions between breeding sows of Landras breed and Belarusian meaty there was not observed. From sows of both breeds in average per farrowing there was obtain 11,0 - 11,2 piglets, including 10,4 - 10,5 live piglets, that exceeded requirements of the first class of the instruction on evaluation of pigs on 4,0 - 5,0%. At the same time, sows of the Belarusian meaty breed had litter weight at weaning in 40 days of 104 kg, that was authentically higher on 8 kg or on 8,3% (Р less than 0,001), than sows of Landras breed. In each breed there were some distinctions in sow productivity by families and in breeding with boars of different lines.

In the conditions of the Republic of Belarus there was studied the propagation, botanical characteristic, chemical composition and pharmacological properties of marsh cinquefoil (Comarum palustre) and its application in the veterinary practice against strongylatosis (Strongylata) of gastrointestinal system of cattle young stock. Reserch results showed that the perennial herbage plant marsh cinquefoil from Rosales (Rosaceae) family possessed different therapeutic properties: antipyretic agent; styptic agent; diuretic agent; bonding agent; wound healing substance; tonic agent; promotoring agent. Research results showed that the preparative forms (broth; liqueur; liquid juice; powder) of marsh cinquefoil possessed an active agent proanthocyanidin, a condensed tanning substance which were included into composition of a polyphenolic complex and proved to be efficient for treatment of cattle young stock strongylatosis.

In the conditions of the Republic of Belarus there were analyzed the doses and efficiency of application of selenium in composition of a mixed fodder KP-2 in diets of bull calves of at their breeding for meat. In course of the study the was developed a formula of a mixed fodder with various doses (0,1; 0,2; 0,3 mg per 1 kg of a dry matter of a ration) of selenium; there was studied the influence of different selenium doses in mixed fodders on palatability of diets, their digestibility, use of nutritive elements and hematological indexes of animals. Also, there was analyzed the influence of different doses of selenium on bull calves growing intensity. There was given the zootechnical and economic evaluation of usage of selenium for bull calves. Selenium dose of 0.2 milligram per 1 kilogram of dry matter proved to be the most efficient and promoted the increasing of average daily body weight gain on 10.9%.

Analysis of data on distribution of clinicopathologic symptoms of rhinotracheitis, parainfluenza-3, bovine viral diarrhoea, clamidiosis, rhinosyncytial virus, adenovirus diseases, rotaviral diseases, coronavirus infections of cattle, viral transmissible gastroenteritis, and respiratory reproductive syndrome of swine, rinderpest, rabies and Aujesky disease of agricultural animals in the conditions of the Republic of Belarus was realized. There were given descriptions of diagnostic tests and vaccines for disease prevention used in Belarus and other countries. Treatment regimen and methods and other elements of prophylaxis were presented. There was given an analysis of prophylactic efficiency of produced medicine drugs

State of immune system of broiler chickens after administration into their diets of nonspecific immunostimulative drugs – bacterial liposaccharide Alveozan and spore-forming aerobic bacterium Bac. Alvei (KMIEhV-11) and probiotic on the basis of lactic acid bacillus Dialakt was studied in the conditions of the Republic of Belarus. In course of the study there was proved that the analyzed preparations had expressed immunogenic activity, rendered the positive influence on natural resistance of broiler chickens. Under action of preparations Alveozan and Dialakt in broiler chickens there were stated the following changes: improvement of protein absorption from gastro-intestinal tract in chickens at the age up to 19 days; there was achieved a hepatic protection effect at birds at the age up to 36 days. The specified changes did not depend on application regimen of the given preparations.

In the conditions of the Republic of Belarus there was studied a therapeutic effectiveness and influence on milk productivity of 22% Timbendazole after spontaneous infestation of cows with fascioliasis (Fasciola hepatica). As a result of studies the Timbendazole 22% proved to be highly efficient against Fasciola hepatica in cattle – from 92,9% up to 100% (in comparison with Albendatimum-100 granulated material the efficiency of which was 88-90%). As a result of cows treatment by anthelmintics – Timbendazole 22% and Albendatimum-100 against Fasciola hepatica there was stated the substantial increasing of milk productivity of animals (on 23,4 and 11,0%, respectively) in comparison with animals which were not administratec with mentioned above preparations.

A technology of application autolysis of fodder yeasts (AFY) for the production of products with higher protein content, digestible aminoacids and other nutritive and biologically active substances in comparison with the standard fodder yeasts (provit) was tested in the conditions of the Republic of Belarus by an example of three groups of swine. Animals of the first (control) group were fed with combined feed SK-26 with addition of 2% of provit. Animals of the second group were fed with combined feed SR-26with addition of 2% of AFY, the third group - with addition 4% of AFY. Provit and AFY were included into combined feed instead of excluded protein components in equivalent number. Research results showed that autolysis of fodder yeasts did not render negative influence on productivity of fattening stores. Average daily weight gain of stores was 637-674 g. Calculation of economic efficiency of combined feeding application of 2 and 4% of AFY showed that application of 2% AFY was more economically profitable