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Iron-fortified recombinant Saccharomyces cerevisiae producing Sus scrofa ferritin heavy-chain recovers iron deficiency in mice
2012
Lim, H., Kangwon National University, Chuncheon, Republic of Korea | Kim, J.T., Kangwon National University, Chuncheon, Republic of Korea | Kim, M.D., Kangwon National University, Chuncheon, Republic of Korea | Rhee, K.J., Yonsei University, Wonju, Republic of Korea | Jung, B.D., Kangwon National University, Chuncheon, Republic of Korea
In this study, we produced iron-fortified yeast (Saccharomyces cerevisiae) producing Sus scrofa ferritin heavy-chain to provide iron supplementation in anemic piglets. We determined whether iron-ferritin accumulated in recombinant yeasts could improve iron deficiency in mice. C57BL/6 male mice exposed to Fe-deficient diet for 2 weeks were given a single dose of ferrous ammonium sulfate (FAS), ferritin-producing recombinant yeast (APO), or APO reacted with iron (Fe²+) (FER). The bioavailability of recombinant yeasts was examined by measuring body weight gain, hemoglobin concentration and hematocrit value 1 week later. In addition, ferritin protein levels were evaluated by western blot analysis and iron stores in tissues were measured by inductively coupled plasma spectrometer. We found that anemic mice treated with FER exhibited increased levels of ferritin heavy-chain in spleen and liver. Consistently, this treatment restored the iron concentration in these tissues. In addition, this treatment significantly increased hemoglobin value and the hematocrit ratio. Furthermore, FER treatment significantly enhanced body weight gain. These results suggest that the iron-fortified recombinant yeast strain is bioavailable.
اظهر المزيد [+] اقل [-]Effect of administration with fat-free diet and dietary iron on polyunsaturated fatty acid, vitamin E and their derivatives in male rats
1990
Huh, R.S. | Kim, Y.H. | Do, J.C. | Lee, Y.H. | Choi, Y.S. (Kyungpook National University, Taegu (Korea Republic). College of Veterinary Medicine) | Kim, S.H. (Korea Research Institute of Chemical Technology, Taejon (Korea Republic))
Effect of dietary iron and vitamin E deficiency on polyunsaturated fatty acids and their derivatives in rat
1988
Huh, R.S. | Do, J.C. | Kim, S.T. (Kyungbook National Univ., Taegu (Korea R.). Coll. of Veterinary Medicine) | Kim, S.H. (Korea Institute of Chemistry, Seoul (Korea R.))
This study was designed to elucidate the effects of iron, a well known catalyst of lipid peroxidation, on the contents of phospholipids, unsaturated fatty acids composed in phospholipid molecules and their derivatives, prostaglandins, and the composition changes of fatty acids contained in phospholipids. Iron decreased the contents of phospholipids and its components of unsaturated fatty acids. Catalytic action of iron decreased the composition rates of linoleate and linolenate composed in phospholipid molecules, while that of arachidonate was inclined to increase. The content of arachidonate was increased and that of prostaglandins was decreased without regard to increase the precursor of prostaglandins. It may be concluded that the decreases of the activities of prostaglandins and the increase of arachidonate are due to inhibition of the activities of enzyme systems responsible for prostaglandin synthesis by lipid peroxides produced by the catalyst of iron
اظهر المزيد [+] اقل [-]Effect of dietary vitamin E on the lipid peroxidation by dietary iron injected to male rats
1991
Huh, R.S. | Kim, Y.H. | Do, J.C. | Choi, Y.S. | Cheong, C.W. (Kyungpook National Univ., Taegu (Korea Republic). Coll. of Veterinary Medicine)
Studies on the safety of recombinant bovine somatotropin in dairy cow, 1; Effects of recombinant bovine somatotropin on mineral composition in milk of dairy cows
1991
Lee, M.H. (Seoul National Univ., Suwon (Korea Republic). Coll. of Veterinary Medicine) | Cho, T.H. (Rural Development Administration, Anyang (Korea Republic). Veterinary Research Institute)
Effect of administration of iron on the lipid concentrations in the RBC membrane and plasma
1985
Kim, S.H. (Korea of Chemical Inst., Seoul (Korea R.)) | Huh, R.S. | Park, H.K. | Do, J.C. | Lee, Y.H. (Kyongbuk National Univ., Taegu (Korea R.))
This study was attempted to verify the mechanisms of RBC survival time shortened with vitamin E deficient and decrement of phospholipid concentrations by administration of iron. The concentration of iron in basal ration (group A and group B) was 40 mg/kg of feed, and the final concentrations of iron in the Fe (OH)3 supplemented-rations (group C and group D) were 13,496 mg/kg and 26,973 mg/kg, respectively
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