The control of gastrointestinal nematodes (GINs) in small ruminants is principally dependent on anthelmintic therapy, which encounters the rising problem of anthelmintic resistance (AR) development. Veterinarians reported anthelmintic failure in several sheep farms in Arbat District, Sulaymaniyah, northern Iraq, which called for a systematic study about the efficacy of three commonly used drugs: albendazole, ivermectin, and levamisole.

This study presents two clinical cases in Chinchilla and Himalayan rabbits, exhibiting symptoms such as alopecia, skin lesions, and ear lesions. Skin scrapings and fecal samples were collected and processed, revealing the presence of Sarcoptes scabiei mites, Psoroptes cuniculi mites, and Eimeria oocysts. Treatment involved subcutaneous administration of Ivermectin (0.2 mg/kg), accompanied by supportive and topical application of Benzyl benzoate. The rabbits displayed clinical improvement, with complete recovery observed within 30 days.

A three-month-old female New Zealand White Rabbit, weighing about 1.4 kg was brought to the Veterinary Clinical Complex, Veterinary College and Research Institute, Tirunelveli with ahistory of intense pruritis and alopecia all over the body. Clinical observation revealed crusty lesions on the nose,ear margin and toes. Microscopic examination of the deep skin scraping revealed the presence of Psoroptes cuniculi mite. The rabbit was treated with an injection Ivermectin @ 0.4 mg/kg sub-cutaneous and an injection of Chlorpheniramine maleate @ 0.4 mg/kg intramuscular and further advised the owner to give HITEK® oral solution (Ivermectin) @ 0.4 mg/kg PO once a week and Benzyl benzoate I.P. solution topically daily for a continuous period of one month along with multivitamin supplementation (Multistar pet®) @ 2 ml PO BID. The rabbit recovered successfully without any drug side effects (Tandem usage of ivermectin and Benzyl Benzoate).

A female Ongole calf aged one year and nine months was found to have nodular development around the left eye and neck region. Clinical examination revealed that the calf had cutaneous papilloma (wart), which was treated with autohemotherapy, ivermectin and levamisole injections along with placement of a ligature around wart's base. On the third day of treatment, a large papilloma on the left lower eyelid dried up and sloughed off. On the tenth day of therapy, the warts on the upper eyelid and neck began to dry and flake off, leaving behind barely visible scars at the original growth sites. The animal underwent an uncomplicated recovery and completely recovered from the ailment.

Antiviral activity of ivermectin was examined against R2B strain of Newcastle disease virus in 9 - day old embryonated chicken eggs. Five distinct concentrations (500, 250, 100, 50, 10 µg/mL) of ivermectin were used in the study. Haemagglutination test was performed to determine the antiviral activity of ivermectin by using chicken RBC. The results revealed that ivermectin can exert a significant antiviral activity against Newcastle disease virus at higher concentrations (500, 250 and 100 µg/ml) but with cytotoxic effects. On the contrary a moderate to weak antiviral activity without cytotoxicity was demonstrated at lower concentrations (50, 10 µg/ml).

Antiviral activity of ivermectin was examined against R2B strain of Newcastle disease virus in 9 - day old embryonated chicken eggs. Five distinct concentrations (500, 250, 100, 50, 10 µg/mL) of ivermectin were used in the study. Haemagglutination test was performed to determine the antiviral activity of ivermectin by using chicken RBC. The results revealed that ivermectin can exert a significant antiviral activity against Newcastle disease virus at higher concentrations (500, 250 and 100 µg/ml) but with cytotoxic effects. On the contrary a moderate to weak antiviral activity without cytotoxicity was demonstrated at lower concentrations (50, 10 µg/ml).

The transmissible venereal tumour (TVT) is a contagious neoplasm that is sexually transmitted between dogs. TVT lesions affect the mucus membranes of the external genitalia in dogs of both sexes. Tumour masses are seen in the caudal aspect of the penis and frequently the prepuce area in males and the posterior vaginal area, particularly the vestibule vaginal junction of females. Sixteen bitches of various ages (2-6 years) and breeds were brought to the clinics at Veterinary Clinical Complex, Gannavaram with the history of continuous oozing of blood from vagina, anorexia and depression. All these were diagnosed as TVT based on the history, clinical symptoms and cytological examination and therapy was initiated. At weekly intervals, all the bitches were administered with combination therapy of Vincristine sulphate (0.025 mg/kg body weight, strict and slow I/V) and Ivermectin (0.2 mg/kg body weight, strict S/C) for four consecutive weeks. All of the bitches underwent significant reduction in tumour size with improvement in general health during the course of therapy with exception that one bitch showed signs of anorexia and dullness.

A female Ongole calf aged one year and nine months was found to have nodular development around the left eye and neck region. Clinical examination revealed that the calf had cutaneous papilloma (wart), which was treated with autohemotherapy, ivermectin and levamisole injections along with placement of a ligature around wart's base. On the third day of treatment, a large papilloma on the left lower eyelid dried up and sloughed off. On the tenth day of therapy, the warts on the upper eyelid and neck began to dry and flake off, leaving behind barely visible scars at the original growth sites. The animal underwent an uncomplicated recovery and completely recovered from the ailment.

This study presents two clinical cases in Chinchilla and Himalayan rabbits, exhibiting symptoms such as alopecia, skin lesions, and ear lesions. Skin scrapings and fecal samples were collected and processed, revealing the presence of Sarcoptes scabiei mites, Psoroptes cuniculi mites, and Eimeria oocysts. Treatment involved subcutaneous administration of Ivermectin (0.2 mg/kg), accompanied by supportive and topical application of Benzyl benzoate. The rabbits displayed clinical improvement, with complete recovery observed within 30 days.

A three-month-old female New Zealand White Rabbit, weighing about 1.4 kg was brought to the Veterinary Clinical Complex, Veterinary College and Research Institute, Tirunelveli with ahistory of intense pruritis and alopecia all over the body. Clinical observation revealed crusty lesions on the nose,ear margin and toes. Microscopic examination of the deep skin scraping revealed the presence of Psoroptes cuniculi mite. The rabbit was treated with an injection Ivermectin @ 0.4 mg/kg sub-cutaneous and an injection of Chlorpheniramine maleate @ 0.4 mg/kg intramuscular and further advised the owner to give HITEK® oral solution (Ivermectin) @ 0.4 mg/kg PO once a week and Benzyl benzoate I.P. solution topically daily for a continuous period of one month along with multivitamin supplementation (Multistar pet®) @ 2 ml PO BID. The rabbit recovered successfully without any drug side effects (Tandem usage of ivermectin and Benzyl Benzoate).